1. An Introduction to the Kinetic Evaluation Software KinGUI
Dr. Dieter Schäfer
Monheim, Germany
FOCUS Kinetics Training • Washington • January 2006

2. ... is a kinetic evaluation software with a Graphical User Interface
What is KinGUI ?
KinGUI ...
... is a kinetic evaluation software with a Graphical User Interface
… can handle almost all relevant metabolic schemes
… complies with the rules and reporting requirements of FOCUS Kinetics (except water/sediment systems)
FOCUS Kinetics Training • Washington • January 2006

3. What is KinGUI ?
KinGUI ...
… is based on the commercial software package MatLab
… uses standard mathematical methods and approaches
minimisation of the sum of squared differences
Runge-Kutta method for numerical solution of the differential equations
Levenberg-Marquardt algorithm for the parameter optimisation
FOCUS Kinetics Training • Washington • January 2006

4. … was developed by BCS and an ECPA Workgroup
What is KinGUI ?
KinGUI ...
… was developed by BCS and an ECPA Workgroup
… will be freely available in its executable version
… is by no means perfect (yet), and will undergo further testing and validation
… is only one of several software tools for kinetic evaluations according to FOCUS, and is used here only as an example
FOCUS Kinetics Training • Washington • January 2006

5. Graphical User Interface
Structure of KinGUI
requires full MatLab software package
MatLab version
of KinGUI
MatLab tool
set of text files (m-files) that can be interpreted by MatLab
Graphical User Interface
set of MatLab text files
MatLab Compiler
executable version
of KinGUI
requires pre-installed MatLab environment
FOCUS Kinetics Training • Washington • January 2006

6. the pre-installed MatLab environment
How to work with KinGUI
What you need to start:
the pre-installed MatLab environment
the executables (kingui.exe, kingui.ctf)
an appropriate input file
a conceptual model of the metabolic scheme
for a detailed introduction to KinGUI refer to the User Manual and the Step-by-Step Guide (available as print-outs and on CD)
FOCUS Kinetics Training • Washington • January 2006

7. short presentation of KinGUI: parent and one metabolite, SFO kinetics
How to work with KinGUI
short presentation of KinGUI: parent and one metabolite, SFO kinetics
FOCUS Kinetics Training • Washington • January 2006