1. Conclusion In conclusion, preliminary data from this nutrition intervention study suggest that a well balanced Mediterranean-type diet is able to reduce several metabolic risk factors in Greek patients with CM diseases. Purpose Purpose A prospective, randomized, controlled nutrition intervention study in order to evaluate the impact of a 6-month balanced Mediterranean- type diet on cardiovascular risk factors in Greek adults with known cardiometabolic (CM) diseases. SubjectsMethods Subjects - Methods We present here preliminary results for 384 patients from a total of 8000 estimated to finally participate in the study, recruited from 50 randomly selected municipalities in Greece. From these 384, 79.9% had obesity, 19% type 2 DM, 55.1% hyperlipidemia, 50.6% hypertension and 14.6% cardiovascular disease (CVD), e.g. coronary disease or stroke. All subjects were randomized into 2 groups and followed for 6 months. The intervention group (I) received a Mediterranean healthy diet personalized in calories and nutrients according to the patient’s diseases, and was followed monthly by a dietitian, whereas the control group (C) did not receive any dietary counseling. Measurements: BMI, %Body Fat (%BF) by BIA, waist circumference(W), serum lipids (TC,TG,LDL- C,HDL-C), Fasting plasma glucose (FPG), HBA1c (only in diabetic patients), Systolic (SBP) and Diastolic (DBP) blood pressure. Table 1: A nthropometric and metabolic parameters before and after intervention (duration of 6 months) A Mediterranean-type Nutrition Intervention Program in Greek Municipalities for Patients with Cardiometabolic Diseases MARIA CHASAPIDOU, THEMISTOKLIS TZOTZAS, IOANNIS PAGKALOS, KONSTANTINOS TZIOMALOS, KONSTANTINA PAPADIMITRIOU Department of Nutrition and Dietetics, TEI Thessaloniki, Greece Percentage of mean difference p ΒΜΙ - 4.0% < 0.001 < 0.001 % Body Fat - 2.8% < 0.05 W (cm) - 4.1 % < 0.001 LDL-C (mg/dl) - 7.9% = 0.05 FPG(mg/dl) - 7.1% < 0.001 SBP (mmHg) - 5.1% < 0.05 Intervention Group (Ι) BeforeAfterp ΒΜΙ 33.7 ±5.6 32.5±5.4 < 0.001 % Body Fat 39.4±8.4 38.2±9.0 0.002 W (cm) 106.7±14.1 102.5±12.7 P < 0.001 LDL-C (mg/dl) 137.0 ± 32.5 121.7 ± 28.4 0.004 FPG(mg/dl) 107.6 ±21.3 100.8 ±19.1 0.001 SBP (mmHg) 83.5 ±9.8 81.1 ±10.1 0.035 REFERENCES 1.Ezzati M and Riboli Ε. Behavioral and Dietary Risk Factors for Noncommunicable Diseases. N Engl J Med 2013;369:10. 2.Lim SS, Vos T, Flaxman AD, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2224-60. 2014 – SAN FRANCISCO, CA ADAs 74 th Scientific Sessions Results A total of 316 patients [181 group (I) and 135 group(C)], aged 58±4, 0 y, 77,5% women, age and sex-matched, finally completed the study. Anthropometric and metabolic parameters before and after intervention in group (I) and percentage of significant mean difference (in parenthesis) between groups (I) and (C) were as follow: Table 2: Percentage of significant mean difference between groups (I) and (C)