1. TRIGGERFISH Glaucoma Monitoring System BME 181 Brittany M. Alphonse Biomedical Engineering

2. Table of Contents  Glaucoma  Current Glaucoma Monitoring Systems  Triggerfish Glaucoma Monitoring System  Triggerfish System Components  Benefits

3. Glaucoma  Progressive and Irreversible Disease  leads to blindness  Deterioration of Optic Nerve  fluid accumulates in eye  high levels of liquid inside eye  Diameter of cornea changes  Asymptomatic  Contributor of disease:  frequent changes in pressure over the span of a day  high peaks in levels during night  4% of population is affected  40+ years of age

4. Current Glaucoma Monitoring Systems  Measures static intraocular pressure  Single Snapshots in Time  taken during the day when pressure is lowest  Monitoring in Overnight Sleep Labs  cumbersome  expensive  Frequent Punctual Measurements  affects intraocular pressure  checks pressure peaks

5. Triggerfish System  Created by SENSIMED  First of its Kind on the market  constant reading device  Safety Approval in Europe last year  Expected U.S. Food and Drug Administration Approval in late 2011  Non-Invasive Continuous Monitoring System  Measures Intraocular Pressure up to 24 hours  Does Not Interfere with Normal Vision  Constant Reading for Fraction of Price

6. Triggerfish System Components  Disposable Contact Lens  soft  hydrophilic  silicone  sensor and microprocessor on outer edge  MEMS Sensor  strain gauge monitors diameter change in cornea  Telemetry Microprocessor  Processes level changes  transmits to receiver Sensor and Processor

7. Components Continued  Circular Antenna  taped around the eye  Sends Energy to Sensor  Receives Measurement Information  Connected to Portable Recorder  thin flexible data cable Antenna

8. Components Continued  Battery Powered  Stores Measured Information  Wirelessly Uploads Information  Worn Around Neck  Ophthalmologist Receives Information  Visualize Intraocular Pressure Profile Recorder/ ReceiverSoftware

9. Benefits of Triggerfish System  Improved Understanding of Pressure Change  pressure during day versus night  More Efficient  Personalized Drug Delivery and Treatment  Adapt Treatment  dependent on changing conditions  Sensor is Placed Outside of Vision Field  Early Diagnosis and Treatment

10. References for Pictures  http://www.sensimed.ch/S-Trig-benefits.htm  http://www.technologyreview.com/business/24931 /page1/  http://www.sensimed.ch/S-Trig-solution.htm