1. Dr Caroline Barelle MBA Giving birth to a biotech........ where’s the pain relief ?!

2. University Fibrinolysis - PhD BSc Biochem

3. University Academia Medical mycology

4. University Academia PI

5. University Biotech Academia

7. 7

8. University Biotech Pharma Academia

9. 9

10. University Biotech Pharma The biggest Pharma Academia

11. University Biotech Pharma The biggest Pharma Academia ?

12. University Biotech Pharma The biggest Pharma Academia Asset portfolio IP/domains

13. University Biotech Pharma The biggest Pharma Academia Investment

15. 15 Takes a long time and a lot of money

16. Medical devices, Clinical Diagnostics,  Lower risk, lower return  Potential for early revenues  Exit often trade-sale Drug discovery  High risk  Makes nothing, sells nothing  99% chance of failure  Consumes loads of cash  Returns are staggering if successful

17. Medical devices, Clinical Diagnostics,  Lower risk, lower return  Potential for early revenues  Exit often trade-sale Drug discovery  High risk  Makes nothing, sells nothing  99% chance of failure  Consumes loads of cash  Returns are staggering if successful

18. SeedSeries ASeries BSeries C

19. IP from University/parent body Technology validation – “Proof of Concept” Commercial prototype and early pre – clinical trials. Idea generation and validation Technology platform and IP broadening Management team & Scientific group hiring Partnership and building company infrastructure Early Stage – Start up Continue with clinical development (Launching of product) and prepare exit (Eg., IPO) Aim for cash flow, break – even and lastly profit Late stage – Expansion/public offering

20. Asset portfolioProposalsPre-commercialisation cashBuild team and company value

21. Science Commercial Investor ready Value proposition BP IP Investors Consultants Milestones CROs Reporting Meetings Customers Secure seed/series A Value build Conferences Collaborations

22. 22 Lead the Science Operations Business Development Commercialisation/Corporate Alliance management Reports Due Diligence IP Papers Conferences BioPartnering Budget

23. 23 Articles of association Shareholding Legal Employee contracts Facilities Finance IP Consultants SAB Chair Directors NEDs Marketing Website HR Organizational Development Press The next tranche of cash!

24. 24 A good team External support Be realistic Enjoy

25. 25 Questions ? ?