1. Syncope J. Ned Pruitt II, MD Associate Professor of Neurology Medical College of Georgia

2. Syncope Syncope – a transient loss of consciousness with a loss of postural tone caused by a brief global reduction or cessation of cerebral blood flow – Causes - cardiac, neurlogic, vascular, and psychiatric

3. Clinical Manifestations of Syncope “Dizzyness” or dysequilibrium – visual changes “greying out” - mental clouding – deafness – nausea – loss of postural tone Rostral to caudal progression Myoclonus – “jerking” not seizure activity Rapid recovery of consciousness without a post-ictal confusion or exhaustion No focal neurologic before or after event

4. Causes of Syncope Cardiovascular – – Decreased preload – hypovolemia/hemorrhage, Valsalva manuever – Decreased iontrophy – cardiac ischemia, cardiomyopathy – Dysrhythmia - Bradycardia - asystole, carotid sinus hypersensitivity, micturtion, defecation Tachycardia - supraventricular or ventricular

5. Causes of Syncope Cardiovascular (cont’d) – Flow obstruction – pulmonary embolism, pulmonary hypertension, aortic stenosis, iodopathic hypertrophic subaortic stenosis, value disease – Tamponade – Anemia

6. Causes of Syncope Neurologic – Neurocardiogenic sycope – “the faint” Vasovagal syncope – Autonomic insufficency Medications – alpha and beta blockers Peripheral neuropathy – diabetes, GBS Adrenal insufficiency Prolonged bedrest syrinx

7. Causes of Syncope Neurologic - (cont’d) – Increased intracranial pressure – SAH, shunt malfunction, obstructive hydrocephalus, venous sinus occlusion – Vertebral artery disease – dissection with embolus, subclavian steal – Hyperventilation

8. Symptoms of Autonomic Insufficiency Orthostatic hypotension – “dizzy” with change in position Dry mouth Constipation or obstipation Impotence Blurred vision

9. Syncope Workup History and physical BP in both arms BP lying, sitting and standing ECG, cardiac event monitor or loop recorder Rarely EEG MRI and CT of little use if neuro exam is normal

10. Syncope Treatment Cardiac – pacemaker, medications if low CO, defibrillator Removal of offending medications Treatment of vascular disease Counciling and recognition – paperbag Autonomic insufficiency – SSRI, NaCl, midodrine,