2. ‘advances discoveries that transform our understanding of brain function and translate into innovative solutions for health and society’

3. Perception,Cognition Behavior Cell and molecular biology of neurons Neural Circuits The Spectrum of Brain Science What are the response properties of neurons? How do these properties contribute to perception, cognition, and behavior? How are these properties generated? How do alterations in cell and circuit properties contribute to abnormal brain function?

4. Neurotechnology Neural Circuits and Behavior Brain to Society Neuropsychiatric Disorders DIBS Interdisciplinary Thematic Cores Developing new techniques for monitoring and controlling neural activity. Defining how the spatio-temporal activity patterns in defined populations of neurons contribute to brain function. Exploring the neural basis of cognitive processes that are particularly relevant to society: decision-making, communication, and social interactions. Determining the neural basis and developing treatments for neuropsychiatric disorders: autism, depression, schizophrenia, addiction. ‘promote innovative approaches to problems of nervous system function that lie at the boundaries of traditional disciplines’

5. Neurotechnology Neural Circuits and Behavior Brain to Society Neuropsychiatric Disorders Developing new techniques for monitoring and controlling neural activity. Defining how the spatio-temporal activity patterns In defined populations of neurons contribute to brain function. Exploring the neural basis of cognitive processes that are particularly relevant to society: decision-making, communication, and social interactions. Determining the neural basis and developing treatments for neuropsychiatric disorders: autism, depression, schizophrenia, addiction. Modeling neural function Data analysis Application of computational approaches

6. 6 1 2-3 4 5 5-12,000 synapses/pyramidal cell Modeling neural function Data analysis

7. Application of computational approaches Modeling synaptic function Sri Raghavachari

8. Application of computational approaches Modeling circuit function Rodney Douglas Kevan Martin

9. 100 um Application of computational approaches

10. 100 um Application of computational approaches

11. 100 um Application of computational approaches FMRI techniques for assessing connectivity

12. Neurotechnology Neural Circuits and Behavior Brain to Society Neuropsychiatric Disorders Developing new techniques for monitoring and controlling neural activity. Defining how the spatio-temporal activity patterns In defined populations of neurons contribute to brain function. Exploring the neural basis of cognitive processes that are particularly relevant to society: decision-making, communication and social interactions. Determining the neural basis and developing treatments for neuropsychiatric disorders: autism, depression, schizophrenia, addiction. Modeling neural function Data analysis Application of computational approaches Columbia University Who's Afraid of Chaotic Networks? Models of Sensory and Motor Processing in the Face of Spontaneous Neuronal Activity 12:00pm on Tuesday, September 9, 2008 Larry Abbott