1. Jamelle E. Banks, MPH Sarah Glavin, PhD Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH

2.  Are we doing a good job selecting investigators, projects, etc.?  Does the work we support meet quality standards?  Is a P01 better than 3 R01s?  If we issued a grant and nobody published, would it make a sound?  Should we support more research in area X v. area Y?

3.  What is the NIH “market share”?  Who are the other funders in the field?  What do the other funders support, compared with NIH? ◦ Overlap/duplication ◦ Areas to collaborate and potential collaborators  Where are the gaps in the research?  Where are most of NIH publications along the research continuum (basic, clinical, translational)?  Who is using NIH findings?

4.  Start with “the world”, and then pull NIH as a subset OR  Start with NIH, then search for “the world”

5.  Start with “the world”, and then pull NIH as a subset  Advantages: ◦ Conceptually cleaner/less biased ◦ Less time and resources  Disadvantages: ◦ Difficult to characterize an NIH program as such, because you often do not capture the whole program ◦ Most likely to miss more basic research, so may understate NIH impact

6.  Start with NIH, then expand to “the world”  Advantages: ◦ Easier to check whether searching “the world” properly captures NIH publications ◦ Can build criteria for “the world” search to best match NIH program  Disadvantages: ◦ More time and resource intensive ◦ May be biased in favor of including NIH research

7.  Specialized Cooperative Centers Program in Reproduction and Infertility Research (SCCPRIRs)  16 center grants, $19.6 M in FY 2008 from NICHD  Largely basic science research in infertility and reproduction and some clinical research  Annual publications range from 108 to 170 over past 6 years

8.  How do SCCPRIRs fit into the world of infertility and reproduction research? ◦ Develop list of SCCPRIRs publications from progress reports and grant acknowledgements – n=121 ◦ Use SCCPRIRs keywords to search ISI database for other literature in the field  The world’s n ranged from 6,316 to 30,880 articles (depending on search parameters)

9.  SCCPRIRs “market share” 0.4% to 2%  Areas of research and journals were fairly similar between SCCPRIRS and the broad literature ◦ Broad literature included more publications specifically focused on animal reproduction ◦ Broad literature emphasized reproductive cancers to a greater degree than SCCPRIRs program

10. Journal NameRank SCCPRIRS (most =1) Rank in “world” (most =1) Endocrinology16 Journal of Clinical Endocrinology and Metabolism 213 Journal of Biological Chemistry324 Biology of Reproduction43 Molecular Endocrinology531 PNAS626 Molecular and Cellular Endocrinology 77 Endocrine849 Fertility and Sterility91 Human Reproduction102 An Example: The SCCPRIRs Program

11.  Other funding sources for reproduction and infertility research ◦ SCCPRIRs grants are not co-funded, but SCCPRIRs researchers received other NIH funding from 7 ICs ◦ Non-NIH research projects on reproduction and infertility were funded by:  Private foundations (small numbers each);  Japan’s Ministry of Science, Education, and Culture  Japan’s Society for the Promotion of Science (quasi- governmental)  Small number of private industry sources

14.  Identify collaborators  Look for possible overlap and duplication  Identify research gaps  Help identify impact of research results  Develop more realistic expectations and understanding of NIH’s role in the larger research community

15.  Questions?  Contact Information: ◦ Sarah Glavin – glavins@mail.nih.govglavins@mail.nih.gov ◦ Jamelle Banks – banksj@mail.nih.govbanksj@mail.nih.gov