1. Slides last updated: October 2013

2. NSCLC is most often diagnosed at an advanced stage Many of the symptoms that do appear with more advanced disease can be mistaken for other illnesses 3  Bronchitis  Pneumonia  Consequences of cigarette smoking 1.MedlinePlus Medical Encyclopedia. Lung cancer - non-small cell. Available from http://www.nlm.nih.gov/medlineplus/ency/article/007194.htm, accessed on 15/09/2013. 2.WebMD. Lung Cancer Health Center: Lung Cancer Symptoms. Available from: www.webmd.com/lung-cancer/lung-cancer- symptoms, accessed on 15/09/2013. 3. Thomas K. Patient information: Lung cancer risks, symptoms, and diagnosis (Beyond the Basics). Available from www.uptodate.com/contents/lung-cancer-risks-symptoms-and-diagnosis-beyond-the-basics, accessed on 15/09/2013. Early lung cancer may not cause any symptoms. 1 25% of people with lung cancer have no symptoms when lung cancer is diagnosed; the remaining 75% develop some symptoms 2

3. Some common NSCLC symptoms 1,2 Mortality is greatly improved when lung cancer is diagnosed early. It is very important to discuss any potential lung cancer symptoms with a health care provider Chronic Cough Worsening Long-Term Cough Weight Loss Hoarseness Haemoptysis Shortness of Breath Loss of appetite Recurrent Bronchitis Wheezing Constant Chest Pain Recurrent Pneumonia Fatigue 1. MedlinePlus Medical Encyclopedia. Lung cancer - non-small cell. Available from http://www.nlm.nih.gov/medlineplus/ency/article/007194.htm, accessed on 15/09/2013. 2. Thomas K. Patient information: Lung cancer risks, symptoms, and diagnosis (Beyond the Basics). Available from www.uptodate.com/contents/lung-cancer-risks-symptoms-and-diagnosis-beyond-the-basics, accessed on 15/09/2013.

4. Symptoms of metastatic NSCLC may vary widely Symptoms of metastatic lung cancer may vary widely and often coincide with the site of tumour metastasis 1 Clusters of symptoms or paraneoplastic syndromes can point to a possible lung cancer 1 Dizziness Bone pain Lumps near the surface of the body, (lymph nodes) often in the neck or above the collarbone Jaundice Weakness or numbness of the arms or legs Headaches Seizures Bleeding or blood clots 1.WebMD. Lung Cancer Health Center: Lung Cancer Symptoms. Available from: www.webmd.com/lung-cancer/lung-cancer- symptoms, accessed on 15/09/2013.