1. Pericardial Disease

2. The normal pericardium is a double- layered sac 1. Visceral pericardium is a serous membrane that is separated by a small quantity (15–50 mL) of fluid 2. Fibrous parietal pericardium

3. 1. The normal pericardium, by exerting a restraining force, prevents sudden dilation of the cardiac chambers, especially the right atrium and ventricle, during exercise and with hypervolemia. 2. Restricts the anatomic position of the heart, minimizes friction between the heart and surrounding structures,prevents displacement of the heart and kinking of the great vessels, 3. Retards the spread of infections from the lungs and pleural cavities to the heart.

4. Total absence of the pericardium, either congenital or after surgery, does not produce obvious clinical disease.

5. Acute Pericarditis Chest pain 1. Severe, retrosternal and left precordial, and referred to the neck, arms, or left shoulder 2. Pleuritic 3. Pericardial pain may be relieved by sitting up and leaning forward and is intensified by lying supine

6. Pericardial friction rub 1. Audible in about 85% of these patients 2. Heard most frequently at end expiration with the patient upright and leaning forward 3. Inconstant

7. ECG 1. Widespread elevation of the ST segments, often with upward concavity 2. Reciprocal depressions only in aVR and sometimes V 1 3. Depression of the PR segment below the TP segment Cardiac enzymes

9. I. Infectious pericarditis A. Viral (coxsackievirus A and B, echovirus, mumps, adenovirus, hepatitis, HIV) B. Pyogenic (pneumococcus, streptococcus, staphylococcus, Neisseria, Legionella) C. Tuberculous D. Fungal (histoplasmosis, coccidioidomycosis, Candida, blastomycosis) E. Other infections (syphilitic, protozoal, parasitic)

10. II. Noninfectious pericarditis A.Acute myocardial infarction B. Uremia C. Neoplasia D. Myxedema E. Cholesterol F. Chylopericardium G. Trauma (1. Penetrating chest wall 2. (Nonpenetrating H. Aortic dissection (with leakage into pericardial sac) I. Post irradiation

11. III. Hypersensitivity or autoimmunity A. Rheumatic fever B. Collagen vascular disease (systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, scleroderma, acute rheumatic fever, C. Drug-induced (e.g., procainamide, hydralazine, phenytoin, isoniazide, minoxidil, anticoagulants) D. Post-cardiac injury 1. Postmyocardial infarction (Dressler's syndrome) 2. Postpericardiotomy 3. Posttraumatic

12. Classification of Pericarditis I. Acute pericarditis (<6 weeks) II. Subacute pericarditis (6 weeks to 6 months) III. Chronic pericarditis (>6 months)

13. Rx Patients with acute pericarditis should be observed frequently for the development of an effusion; if a large effusion is present, the patient should be hospitalized Nonsteroidal anti-inflammatory drugs such as ibuprofen (400–600 mg tid), indomethacin (25–50 mg tid), or colchicine (0.6 mg bid), Glucocorticoids (e.g., prednisone, 40–80 mg daily)

14. Postcardiac Injury Syndrome Previous injury to the myocardium with blood in the pericardial cavity. After a cardiac operation (post pericardiotomy syndrome), after blunt or penetrating cardiac trauma or after perforation of the heart with a catheter. After AMI

15. The principal symptom is the pain of acute pericarditis, which usually develops 1 to 4 weeks after the cardiac injury (1 to 3 days after AMI) but sometimes appears only after an interval of months Pericarditis, fever with temperature up to 39°C (102.2°F), pleuritis, and pneumonitis

16. Cardiac Tamponade

17. The accumulation of fluid in the pericardial space in a quantity sufficient to cause serious obstruction to the inflow of blood to the ventricles results in cardiac tamponade. This complication may be fatal if it is not recognized and treated promptly.

18. The three most common causes of tamponade are neoplastic disease, idiopathic pericarditis, and renal failure Bleeding into the pericardial space after cardiac operations, trauma, and treatment of patients with acute pericarditis with anticoagulants

19. Beck's triad: hypotension, soft or absent heart sounds, and jugular venous distention Electrical alternans of the P, QRS, or T waves should raise the suspicion of cardiac tamponade

20. Paradoxical Pulse Greater than normal (10 mmHg) inspiratory decline in systolic arterial pressure

22. Rx Pericardiocentesis Pericardial window

23. Constrictive Pericarditis

24. 1. acute or relapsing viral or idiopathic pericarditis, 2. trauma with organized blood clot, 3. cardiac surgery of any type, 4. mediastinal irradiation, 5. purulent infection, 6. neoplastic disease (especially breast cancer, lung cancer, and lymphoma), 7. rheumatoid arthritis, SLE, 8. chronic renal failure with uremia treated by chronic dialysis

25. In constrictive pericarditis, ventricular filling is unimpeded during early diastole but is reduced abruptly when the elastic limit of the pericardium is reached, whereas in cardiac tamponade, ventricular filling is impeded throughout diastole

26. RESPIRATORAY VARIATION

28. Weakness, fatigue, weight gain, increased abdominal girth, abdominal discomfort, and edema are common. The patient often appears chronically ill, and in advanced cases there are anasarca, skeletal muscle wasting, and cachexia. Exertional dyspnea is common

29. The cervical veins are distended and venous pressure may fail to decline during inspiration (Kussmaul's sign). Congestive hepatomegaly is pronounced and may impair hepatic function and cause jaundice; Ascites is common and is usually more prominent than dependent edema

30. Constrictive Pericarditis TamponadeCharacteristic Usually absentCommonPulsus paradoxus PresentAbsentKussmaul's sign Often presentAbsentPericardial knock AbsentMay be presentElectrical alternans AbsentPresentPericardial effusion PresentAbsentThickened pericardium Often presentAbsentPericardial calcification