1. Supplemental Figure 1

2. 1000 cells/ well DLD-1 ALDH+/CD133+ DLD-1 ALDH- /CD133- Supplemental Figure 2

3. Supplemental Figure 3

4. Supplemental Figure 4

5. Supplemental Figure 5

6. Supplemental Figure 6

7. Supplemental Table 1

8. Colon cancer cellColon cancer Stem cell DLD-10.501.10 HCT1160.610.20 SW4800.510.62 HT290.960.60 Supplemental Table 2 The half-maximal inhibitory concentrations (IC 50, µM) obtained for GO-Y030 in colon cancer cells and colon cancer stem cells. Cells were incubated with GO- Y030 in triplicate at 37˚C for 72 hours. 3-(4,5-Dimethylthiazolyl)-2,5- diphenyltetrazolium bromide (MTT) viability assay was performed and the absorbance was recorded at 595 nm. IC50 values were determined using Sigma Plot 9.0 Software (Systat Software Inc., San Jose, CA).