1. Immunogenetics chapter 22 select topics pp. 611-620

2. Topic Outline Overview of the Immune System 1 st and 2 nd lines of Defense The Immune System  B cells  The antibody & antibody diversity  Vaccinations  Breast Feeding  Diagnostic applications  T cells  Allergies

3. Immune System and Lymphoid Tissue

4. Let’s take a look at the different types of Leukocytes

5. Monocyte Neutrophil Eosinophil Basophil Dendritic Cell Lymphocyte

6. Epidermis Mucosal lining of GI Ciliated epithelium of respiratory tract EXAMPLES FIRST LINE OF DEFENSE Can by physical and chemical

7. Second line of defense include the following processes:  Phagocytosis  Complement  Interferons  Inflammation  Pyrogens

8. Phagocytosis

9. Complement Cascade

10. 3 rd line of defense “The Immune System”

11. Summary Lines of Defense INNATE ACQUIRED

12. Immune System B cells T cells

14. Lymph nodes are contain high concentrations lymphocytes

15. Let’s look more closely at the B lymphocytes

16. B Cell: humoral or antibody mediated immunity ANTIBODIES=IMMUNOGLOBULINS Humoral Immunity  Matures in bone marrow  Moves to lymph nodes (& other locations)  Secretes antibodies “as plasma cell”  Also creates “memory” B cells B-lymphocyte

17. CLONAL SELECTION

18. Different classes of immunoglobulins or antibodies IgM IgG IgA IgD IgE

19. Antibody Diversity How do we acquire so many different types of antibodies?  Somatic recombination  Junctional diversity  hypermutations

20. Antibody genes are composed of segments V J C

22. Somatic Recombination http://www.bio.davidson.edu/courses/Imm unology/Flash/somaticrecomb.html http://www.bio.davidson.edu/courses/Imm unology/Flash/somaticrecomb.html

23. How are vaccinations related to immunity? Active and Passive

24. Active Vaccinations: Antibody Production Memory Cells!

25. The next part gets tricky Onto T Cells

26. All T cells require cell to cell contact

28. http://highered.mcgraw-hill.com/sites/0072495855/student_view0/chapter24/animation__cytotoxic_t-cell_activity_against_target_cells__quiz_2_.html CD8+ CD4+

29. T Cells VJC (D) These are some of the General characteristics of the T Cell receptor for antigen recognition. + D in the beta chain

30. Cytotoxic T Cell and MHC I Antigen presentation CD8+ cell

31. Cytotoxic T cell= CD8+

33. Tissue Transplantation MHC proteins differ between individuals

34. The major histocompatibility complex is a large group of genes on chromosome 6

35. Helper T Cell and MHC II Antigen presentation

36. B lymphocytes source of antibodies Overview of T lymphocytes

37. Cancer cell being attacked by cytotoxic T cells After release of perforin

39. Allergic Response I.

40. Allergies B cell also directly stimulated IgE