1. SARC Career Development Award Program Richard Gorlick, MD Lee Helman, MD

2. SARC Career Development Award  Fund established 2007  Initial award granted 2009  Incorporated into the SARC sarcoma SPORE in 2013  Purpose To help prepare and support scientists working in sarcoma as they begin their careers as independent researchers

3. SARC Career Development Award  Committee  R. Gorlick, Co-Chair  L. Helman, Co-Chair  J. Crowley  J. Fletcher  M. Thornton  F. Hornicek  D. Lev  C. Mackall  M. van de Rijn  S. Schuetze  L. Schwartz

4. SARC Career Development Program 2014  SARC Sarcoma SPORE Career Development Award  Requires awardees to be US citizens  SARC is interested in continued support of researchers internationally  Two funding opportunities  US based researcher  International researcher

5. SARC SPORE CDA  Criteria  Final year of clinical fellowship or postdoctoral fellowship, or within five years of first faculty appointment  Demonstrated track record of interest and productivity in research relevant to sarcoma  US citizen  Funding Level  $ 100,000 per year, for up to two years

6. International CDA  Criteria  Final year of clinical fellowship or postdoctoral fellowship, or within five years of first faculty appointment  Demonstrated track record of interest and productivity in research relevant to sarcoma  Citizenship outside US  Funding Level  $100,000 per year, for up to two years

7. Application Process  Two step process  Letter of Intent  Full application  Letter of intent due  January 3, 2014  Contact SARC with any questions  sarc@sarctrials.org sarc@sarctrials.org

8. 2009 Career Development Award Recipients Anchorage-independent conditions as a model for micrometastatic disease in osteosarcoma Targeted therapy of Ewing’s Sarcoma via IGF- 1R signaling cascade Sandra Strauss, MD, PhD University College London Joseph Ludwig, MD University of Texas, MD Anderson Cancer Center

9. 2010 Career Development Award Recipients Novel genomic approach to risk-stratify and identify relapse-associated copy number alterations in Ewing’s sarcoma Patrick J. Grohar, MD, PhD Fellow, National Cancer Institute Development of a Small Molecule Therapy Targeting EWS-FLI1 Joshua D. Schiffman, MD Assistant Professor, University of Utah

10. 2011 Career Development Award Recipients Adoptive T-cell therapy for patients with metastatic sarcoma Keila Enitt Torres, MD, PhD University of Texas, MD Anderson Cancer Center The role of the P13K/AKT/mTOR pathway in radiation associated sarcoma (RAS) Seth M. Pollack, MD University of Washington/Fred Hutchinson Cancer Research Center

11. 2012 Career Development Award Recipients Exploiting Argininosuccinate Synthase 1 Deficiency in Sarcoma. Adrián Mariño-Enríquez, MD Harvard Medical School, Brigham and Women’s Hospital, Department of Pathology Genome-wide functional characterization of GIST: Strategies to maximize kinase-inhibitor response Brian A. Van Tine, MD, PhD Washington University, Division of Medical Oncology Director, and Assistant Professor, Division of Medical Oncology

12. 2013 Career Development Award Recipients Simone Hettmer, MD, Dana Farber Cancer Institute Cigall Kadoch, PhD Broad Institute John Shern, MD National Cancer Institute Identifying novel therapies in pediatric RMS using high- throughput screening for inhibitors of the PAX3- FOX01 Oncogenic transcription factor Evaluation of the contributions of candidate RMS-relevant genes/pathways in RMS malignancy Reversing the roles of misdirected chromatin remodeling in human synovial sarcoma

13. 2014 Career Development Application Key Dates  January 3, 2014  Letter of Intent  March 31, 2014  Submission of Grant Proposal  July 1, 2013  Funding Period Begins