1. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Translational Sciences: Purdue Resources Charles Buck Director of Operations Bindley Bioscience Center cbuck@purdue.edu 765-494-2208

2. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Support for Success  Interdisciplinary team approach  Entrepreneurial driven culture  Administrative, business and scientific support  Seed grants for promising research  State-of-the-art research facilities and equipment

3. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Discovery Park Integrated core centers: Nanotechnology Bioscience Entrepreneurship Learning Regenstrief Center for Healthcare engineering Oncological sciences ACCESS – computation Sustainability (GSI) Burton D. Morgan Center for Entrepreneurship Birck Nanotechnology Center Gerald D. and Edna E. Mann Hall Bindley Bioscience Center Discovery Learning Research Center Project research centers and subcenters Infrastructure Administrative Business team – SPS & business office Project coordination Web site integration Special events Technical Research Cores – partnership with academic units Equipment and facilities

4. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Mass Spec profiling informatics

5. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Proteomics enabling longitudinal studies Evaluate patient samples at baseline and 15 months “Consistency of the platform enabled profiling of discrete human plasma samples comprising the largest human proteomic profile dataset to date. All of these data are available publicly for independent analysis and provide a resource for plasma protein biomarker discovery and verification.” healthy15 mo cancer patientsbaseline cancer patients

6. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Combined SPECT and x-ray CT Enables SPECT and CT image registration Multi-pinhole collimators High resolution imaging (350 um voxels) High sensitivity imaging (kBeq source) Data binning relative to biological rhythms Reduces blur List mode acquisition and statistical 3-D image reconstruction algorithm. Improves image quality MiLabs U-SPECT-II/CT Micro SPECT / CT Imaging

7. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Culex-L at work Norepinephrine concentrations during automated (Culex-L) and manual (jugular stick) blood sampling Purdue Translational Pharmacology Superior approach for in vivo pharmacokinetics and pharmacodynamics

8. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Animal models & preclinical studies Terrier bladder cancer model Full service histology laboratory. Two board certified veterinary pathologists available for collaboration. The vet Clinical Trials Group provides the expertise & facilities for animal clinical trials (veterinary) & translational preclinical investigation (human) The Clinical Discovery Lab provides for: analysis and testing of orthopedic /biomedical devices experimental surgery

9. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Body composition, diet, disease Body plethysmography Indirect calorimetry Ingestive behavior

10. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Camp Calcium Gain valuable information about bone health in adolescents to help other children build strong bones in the future. Ethnic group participation Campers are educated about nutrition and bone health. Faculty: Dr. Connie Weaver

11. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org BME/Nano Capabilities Electrical, mechanical, optical, acoustical devices and instruments Nano, micro, macro design and fabrication Both diagnostic and therapeutic (e.g., bionano) device/protocol development Diverse application areas (neurological, cardiovascular, orthopedic, cancer) Links to Indiana medical device companies Extensive benchtop device testing capabilities Preclinical study planning expertise Nano Fab in Birck MRI research/patient center

12. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Tethered Nanocube-Carbon Nanotube Biosensor Enhanced SEM image of the Au/Pd nanocube augmented single walled carbon nanotube (CNT) network glucose sensors. Drs. D. Marshall Porterfield and Tim Fisher Performance Comparison with other available technologies

13. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org SpeechVive ™ Unobtrusive portable device designed to improve speech and communication in patients with PD Uses the Lombard Effect, preserved in patients with PD, to elicit louder and clearer speech spontaneously Designed and built by CTSI biomedical/bionanotechnology team Faculty: Dr. Jessica Huber OTC licensed to AMIPurdue as a development partner Design and engineer productization of prototype Support to positioning device for FDA submission

14. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Alfred E. Mann Institute Purdue - created by a $100 million endowment from the non-profit Alfred E. Mann Foundation for Biomedical Engineering (AEMFBE) The Institute provides comprehensive – Intellectual Property Analysis and Development Market Analysis Regulatory Pathway Planning Reimbursement Strategies Clinical Application Assessment Product Development Process Business Modeling Licensing Strategies Project Selection Product Launch Strategies Quality System Implementation Technical Feasibility Study Industrial Design Product Requirement Specification Clinical Studies Manufacturing Process Validation Competitive Analysis Exit Strategies

15. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Office of Technology Commercialization Nurture Innovation: Trask Innovation Fund 98 innovations Nanoscale investment: ave. $48,000 TIF investments yielded 89 separate commercial licenses TIF supported innovations are licensed at a 45% increase relative to technologies supported by federal funding alone

16. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Office of Technology Commercialization Nurture Innovation: Emerging Innovation Fund Established 2008, seeded by PRF makes a relative microscale investment in select Purdue-related new ventures. Leverage EIF investment to obtain macroscale funding from non-dilutive sources (SBIR, STTR) or institutional investor

17. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org University – business collaboration

18. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org CY2009: Deal Flow

19. ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Thank you for your attention! cbuck@purdue.edu