1. Lecture 13 – Project selection & Signalling Cross Talk BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

2. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure metabolic energy network

3. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure control of food intake

4. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure pancreas Module 7: Figure pancreas

5. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure β-cell signalling Module 7: Figure β-cell signalling

6. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure α-cell signalling Module 7: Figure α-cell signalling

7. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure liver cell signalling

8. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 CREB (Cyclic AMP response element-binding protein) CREB (Cyclic AMP response element-binding protein) CREB (Cyclic AMP response element-binding protein) functions in the control of many different cellular processes: The survival and proliferation of β-cells is regulated by glucose and by various hormones such as glucagon-like peptide-1 (GLP-1) Which appear to act synergistically to activate the CREB co-activators called TORCs Regulating the biosynthesis of Glucagon Activation of neuronal gene transcription responsible for learning and memory Expression of clock genes Expression of brain-derived neutrophic factor (BDNF) Fast-spiking interneurons (Module 12: Figure schizophrenia). The CREB/TORC transcriptional duo play a critical role in energy metabolism peroxisome-proliferator-activated receptor γ (PPARγ) coactivator-1 (PGC-1) PPAR transcription factors - function in liver cell gluconeogenesis Transcriptional regulation aquaporin AQP2 and AQP3 - vasopressin-induced antidiuresis Melanogenesis NMDA receptor hypofunction in schizophrenia.

9. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure wite fat cells

10. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure lipolysis and lipogenesis

11. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure brown fat cells

12. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure liver cell signalling

13. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure glycogenolysis and gluconeogenesis

14. Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012 Module 7: Figure liver cell signalling