1. Medical Devices Summit February 19-20, 2015 Entrepreneurship Focus Cost-Effective Solutions for Low to Medium Volume Manufacturing Endo-Lamina LLC

2. Medical Devices Summit February 19-20, 2015 Entrepreneurship Focus Cost-Effective Solutions for Low to Medium Volume Manufacturing Why entrepreneurs need to know about Manufacturing You don’t make money selling hand-made prototypes Design decisions made early-on have cost ramifications later, and may be very difficult to change later Design decisions affect: End user cost Capital requirements Time to market hartwick@alum.mit.edu www.Endo-Lamina.shopwindowcorp.com

3. Medical Devices Summit February 19-20, 2015 Entrepreneurship Focus Cost-Effective Solutions for Low to Medium Volume Manufacturing HOW DO 3D-PRINTING AND RAPID PROTOTYPING FIT IN WITH OTHER MANUFACTURING PROCESSES? FORM IN WHICH RAW MATERIAL DELIVERED: Typical processes FIXED FORM: FIXED FORM: Machining metals and plastics from bar stock (minimal part-specific tooling, maximum flexibility) hartwick@alum.mit.edu www.Endo-Lamina.shopwindowcorp.com

4. Medical Devices Summit February 19-20, 2015 Entrepreneurship Focus Cost-Effective Solutions for Low to Medium Volume Manufacturing HOW DO 3D-PRINTING AND RAPID PROTOTYPING FIT IN WITH OTHER MANUFACTURING PROCESSES? FORM IN WHICH RAW MATERIAL DELIVERED: Typical processes FIXED FORM: FIXED FORM: Machining metals and plastics from bar stock (minimal tooling) UN-FORMED UN-FORMED : Casting, Powder metallurgy, Thermoset processing, Injection molding (tooling is significant) hartwick@alum.mit.edu www.Endo-Lamina.shopwindowcorp.com

5. Medical Devices Summit February 19-20, 2015 Entrepreneurship Focus Cost-Effective Solutions for Low to Medium Volume Manufacturing WHICH PROCESS IS BEST SUITED FOR PROTOTYPE QUANTITIES? FORM IN WHICH RAW MATERIAL DELIVERED: Typical processes FIXED FORM: FIXED FORM: Machining metals and plastics from bar stock (minimal tooling) UN-FORMED UN-FORMED: Casting, Powder metallurgy, thermoset consolidation, injection molding (tooling is a significant expense) PRE-FORMED: PRE-FORMED: Sheet metal:bending & stamping, Wire: spring winding & wire forms (minimal tooling, except for some stampings ) Endo-Lamina LLC

6. Relative movement Grain shape Material properties StrengthMode FIXED FORM nonenormalisotropichighsubtractive UN- FORMED PRE- FORMED Medical Devices Summit February 19-20, 2015 Entrepreneurship Focus Cost-Effective Solutions for Low to Medium Volume Manufacturing The Details

7. Relative move- ment Grain shape Material proper- ties StrengthMode FIXED FORM nonenormalisotropichighsubtractive UN- FORM ED (PM, mold, cast maximumnormalmostly isotropic variesadditive and incrementally additive (as powder, filament or liquid) PRE- FORM ED Medical Devices Summit February 19-20, 2015 Entrepreneurship Focus Cost-Effective Solutions for Low to Medium Volume Manufacturing The Details

8. Relative move- ment Grain shape Material proper- ties StrengthMode FIXED FORM nonenormalisotropichighsubtractive UN- FORM ED (PM, mold, cast) maxi- mum normalmostly isotropic variesadditive and incrementally additive (as powder, filament or liquid) PRE- FORM ED nonehighly deform ed preferen- tially anisotropic High to extreme- ly high varies Medical Devices Summit February 19-20, 2015 Entrepreneurship Focus Cost-Effective Solutions for Low to Medium Volume Manufacturing

9. Relative move- ment Grain shape Material properties StrengthMode FIXED FORM nonenormalisotropichighsubtractive UNFO RMED (PM, mold, cast) maxi- mum normalmostly isotropic variesadditive and incrementally additive (as powder, filament or liquid) PRE- FORM ED nonehighly deform ed preferen- tially anisotropic High to extreme -ly high varies Medical Devices Summit February 19-20, 2015 Entrepreneurship Focus Conventional processes improve incrementally/additive manufacturing combines certain advantages

10. CASE STUDY: innovative tools for endoscopy and single incision surgery EXISTING TOOLS FOR USED IN ENDOSCOPIC PROCEDURES NON-steerable accessories

11. Expand your reach: innovative tools for endoscopy EXISTING TOOLS NON-steerable accessories Endo-Lamina's TOOLS Steering/deflection NOT dependent on scope

12. hartwick@alum.mit.edu www.Endo-Lamina.shopwindowcorp.com

13. Endo-Lamina.com

14. Endo-Lamina.com Expand your reach

15. Endo-Lamina.com "The work of the individual still remains the spark that moves mankind forward." -Igor Sikorsky