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ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Engaging Hospitals in Research: Implementation Science Jose Azar, MD Medical Director,

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Presentation on theme: "ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Engaging Hospitals in Research: Implementation Science Jose Azar, MD Medical Director,"— Presentation transcript:

1 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Engaging Hospitals in Research: Implementation Science Jose Azar, MD Medical Director, Quality Improvement. Patient safety and Inpatient Hematology/Oncology Unit IU Health Simon Cancer Center

2 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Bridging Healthcare Discovery and Delivery: Implementation Science Fast Adoption of Proven Interventions In Everyday Practice Clinical Trials Health Services Research Implementa tion Science Learning Health System Better Care at Lower Cost

3 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Bridging Healthcare Discovery and Delivery: Implementation Science Implementation research is the scientific study of methods to promote the systematic uptake of research findings and other evidence-based practices into routine practice, and, hence, to improve the quality and effectiveness of health services and care. Implementation Science 2006; 1:1

4 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Consolidated Framework for Implementation Science Un-adapted Intervention Outer Setting Inner Setting Individuals Involved Process Adapted Intervention Adaptable Periphery Core Components Adaptable Periphery Implementation Science, 2009; 4:50

5 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Personalized Medicine Lean/Six Sigma Implementation Science Implementation Science: Sources of Variation in Healthcare Delivery Professional Informed Clinical Decision Making Patient Centered Systems and Processes Zero Error Zero Waste Patient Response Effectiveness of Care Boustani and Azar, 2012

6 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Health Care System: Complex Adaptive System (CAS) Open, dynamic, flexible, adaptive and complex network Complex due to: –Numerous interconnected, semi-autonomous, competing, and collaborating professional members Adaptive due to: –Ability to learn from prior experiences –Dynamic and flexible connecting patterns among its members The performance of a CAS fluctuates over time due to: –Response to the external pressure or stressors –Resiliency of its internal network

7 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Discovering solutions in a CAS: Reflective Adaptive Process (RAP) Process: –Shared Vision, Mission, and Values –Protected Time and Space –Safe Environment –Value Tension and Discomfort –Seek Diversity and Different Perspectives –Timely and ongoing feedback Accomplishments: –Critical Evaluation of Opportunities –Identification the Optimal Interventions –Scalability of positive solutions –Discontinuation of negative solutions

8 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Application: Group-based Problem Solving Indianapolis Discovery Network for Dementia Group-based problem solving and solution generation forum Includes stakeholders from all five major health systems in Indianapolis Mission: –Conduct implementation science research activities –Provide a culture of discovery, cooperation and team work –Disseminate knowledge and innovations Outcome: –ROI of $32M in grant funding (NIH, CMS, PCORI)

9 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Application: Group-based Problem Solving Hospital Unit-Based Innovation Team: Innovation team assembled to create resiliency/adaptability Engage with respect, purpose, empowerment Principles: –Innovation –Lean Methodology –Complexity Science Outcomes: –Rapid Cycle Improvement board – 18 projects in 6 months –Inpatient Relational Coordination based inter-professional daily care rounds

10 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Inpatient Relational Coordination based Inter-professional Daily Care Rounds Relational Coordination Care Delivery Process Team: MD Fellows Residents Bedside RNs PharmDs Care Coordinators Case Managers Social Workers Outcomes: LOS Readmissions Discharge efficiency Falls Patient experience Outcomes: LOS Readmissions Discharge efficiency Falls Patient experience Role Definition to highlight expertise of each role Coaching to Enhance non-MD participation ? ?

11 ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH www.indianactsi.org Engaging Hospitals in Research: Find mutual goals and interest between healthcare research and delivery Focus on patient relevant outcomes in the clinical study design Factor optimal implementation / dissemination into clinical study design Consider economic and financial implications of the clinical study design Remember that healthcare systems are complex adaptive systems rather than linear hierarchical systems


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