1. Determining Properties of Wound Dressings for Negative Pressure Wound Therapy Lora Aboulmouna, Lisa Lewicki, Ryan Frye

2. What is NPWT? The application of sub-atmospheric pressure to a sealed wound for the purpose of removing fluid and stimulating a cellular response through the mechanical stretching of wound tissue. Process: Material inserted into wound bed Material inserted into wound bed Sealant drape Sealant drape Fluid drain tube Fluid drain tube Vacuum Applied Vacuum Applied -50 to -120 mmHg -50 to -120 mmHg

3. Pioneer Technology They aim to discover and create solutions in the healthcare community beginning with advancements in wound care while bridging the gap between healthcare technology and nature. They aim to discover and create solutions in the healthcare community beginning with advancements in wound care while bridging the gap between healthcare technology and nature. Green healthcare Green healthcare Combined therapy of hyperbaric oxygen and negative pressure wound therapy Combined therapy of hyperbaric oxygen and negative pressure wound therapy Discover the benefits of Sorbact and likelihood of commercial success Discover the benefits of Sorbact and likelihood of commercial success Mentor: Josh Smith, Vice President Mentor: Josh Smith, Vice President Advisor: Dr. Jack Fisher, Associate Clinical Professor of Plastic Surgery Advisor: Dr. Jack Fisher, Associate Clinical Professor of Plastic Surgery

4. Wound Dressings Sorbact Gauze KCI Foam

5. Project Goals To determine To determine Material resistance Material resistance Flow rate Flow rate Pressure gradient Pressure gradient Saturation points Saturation points of the three materials in a negative pressure environment. of the three materials in a negative pressure environment. Build a model that provides a controlled environment Build a model that provides a controlled environment

6. Proposed Design Setup Clinical Pressure Ranges: -50 to -120 mm Hg Fluid Vacuum Bernoulli’s Principle: Height of water Fluid velocity Vacuum Pressure Density Head losses Pipe Mesh Membrane Flow meters

7. Design Obstacles Model orientation Model orientation Mesh barrier Mesh barrier Fistula vs. wound Fistula vs. wound Pressure intensity Pressure intensity Fluid analog Fluid analog Water Water Mimic Plasma (saline) Mimic Plasma (saline)

8. Future Directions Determine dimensions of pipe Determine dimensions of pipe Determine ideal fluid Determine ideal fluid Obtain materials to build model Obtain materials to build model Trial and Error Trial and Error Orientation Orientation Mesh barrier Mesh barrier

9. References Borgquist O, Ingemansson R, Malmsjö M. Wound edge microvascular blood flow during negative pressure wound therapy: examining the effects of pressures from -10 to -175 mmHg. Plast Reconstr Surg In press. Borgquist O, Ingemansson R, Malmsjö M. Wound edge microvascular blood flow during negative pressure wound therapy: examining the effects of pressures from -10 to -175 mmHg. Plast Reconstr Surg In press. Ljungh, A, N Yanagisawa, and T Wadström. "Using the principle of hydrophobic interaction to bind and remove wound bacteria." Journal of Wound Care 15.4 (2006): n. pag. Web. 6 Nov 2010. Ljungh, A, N Yanagisawa, and T Wadström. "Using the principle of hydrophobic interaction to bind and remove wound bacteria." Journal of Wound Care 15.4 (2006): n. pag. Web. 6 Nov 2010. Smith, Jan, and Peter Robertsson. Method for Dressing a Wound., 2010. Web. 27 Oct 2010. Smith, Jan, and Peter Robertsson. Method for Dressing a Wound., 2010. Web. 27 Oct 2010. "Science Behind the Therapy — KCI." Science Behind The Therapy. Web.. "Science Behind the Therapy — KCI." Science Behind The Therapy. Web..