1. How is blood glucose regulated by negative feedback regulation? By hormones Made by endocrine gland- Pancreas

2. Lets talk about pancreas… Because pancreas makes the hormones that regulate blood glucose

3. Eat food Blood glucose goes up Q. What does blood do with this glucose? Delivers it to the cells. How? We need a hormone. Pancreas makes the hormone insulin that helps to bring the blood glucose down

5. How does insulin work? It is released in the blood. It binds to the receptors on the cells and unlock the cells. Cells absorb glucose. Why does glucose move from the blood into the cells? Because there is higher concentration of glucose in the blood so it diffuses into cells where concentration is low It is called Diffusion

6. What does blood do with extra glucose? It takes it to liver and muscles They store it as GLYCOGEN (polysaccharide) How does liver take up glucose to store? Hormone insulin… What did insulin help accomplish? It brought the blood glucose down

7. Some cells need more glucose because they are working more than others. So blood needs to carry some glucose all the time. What if blood glucose goes down too much? You have HYPOGLYCEMIA

8. How do you bring the blood glucose levels back up? Pancreas makes glucagon How does glucagon work? It fits the receptors on liver and muscles and signals them to release glucose by breaking down glycogen

9. Why does glucagon only give signal to liver and muscles, and not brain? Because only liver and muscles have the receptors for glucagon. Can you explain how receptors work? They fit with the signal because of their shape

10. In summary, how Pancreas regulates blood sugar? Which type of regulation is this? Negative feedback regulation Can you explain negative feedback regulation? If there is change in one direction, another change happens in the opposite direction

11. Which life function is accomplished by this regulation? Homeostasis Is the ability to maintain a stable/constant internal environment

12. WHO makes hormones?