1. Integumentary System This body system connects to the other systems in many ways!! See handout pg 45. This system consists of the skin and its accessory organs, hair, nails, and cutaneous glands.

2. Functions of the Integumentary System 1. Resistance to trauma and infection ( epidermal cells have lots of KERATIN (protein) strong! 2. Barrier to liquids 3. Vitamin D synthesis 4. Sensation 5.Thermoregulation 6. Social functions

3. Layers of the skin Epidermis: is the top five layers of skin, and contains five different types of cells 1A. Dead cells (keratinocytes) 1B. Living Keratinocytes : most of the epidermal cells, they produce keratin and use UV light to convert a steroid to pre-vitamin D Stratum Corneum 2. Dendritic cells (Langerhans cells) : microphages that fight toxins, microbes, and other pathogens that penetrate the skin, (Immune alarm) Stratum Spinosum 3. Tactile cells (Merkel cells) are receptors for touch Stratum Basale 4. Stem Cells: they go through mitosis to produce keratinocytes Stratum Basale 5. Melanocytes : produce melanin that reacts to sun light to increase sun burn protection S tratum Basale See table 6.1 on page 194

6. 2 nd layer of skin: Dermis Dermis: lies below epidermis, has large amounts of fibrous connective tissue. Composed mainly of collagen, elastic, and reticular fibers. The connective tissue in this layer contains: blood vessels, sweat glands, hair follicles, nail roots, sebaceous glands, smooth muscles,(Piloerector), pressure receptors and nerve endings

7. 3 rd Layer of the Skin: Hypodermis The hypodermis is often called the superficial fascia The fascia contains large amounts of adipose ( subcutaneous fat), connective tissue, blood vessels Adipose tissue pads the body, is a thermal insulation and energy store and is the preferred injection site due to it vascular rate Connective tissue binds the skin to the underlying tissues

8. Skin ColorSkin Color Skin color is determined by amount of melanin produced by melanocytes. There are basically 2 colors: Eumelanin= Brown Black Pheomelanin= Red/Yellow (sulfur containing) Other factors are hemoglobin (red/pink hues) and carotene (yellow/orange…in veggies)

9. Skin Color : can indicate disease or disorders 1. Cyanosis—blueness due to O2 deficiency 2. Erythem— abnormal redness, blush, sunburn 3. Pallor---- ash, pale, too little blood flow, dermal collagen shows through 4. Albanism —lack of melanin..genetic recessive 5. Jaundice– yellowing of skin due to high levels of billirubin, hemoglobin break down product 6. Bronzing—golden brown, Addison Disease, lack of glucocorticoid hormone. 7. Hematoma—bruising, purplish, clotted blood showing through.

10. Types of Skin Markings Friction Ridges: markings on fingertips, form during fetal development Flexion Lines: Lines on digits, palms, wrists, elbows Freckles: flat melanized patches of skin that vary with heredity and sun exposure Moles: same as freckle but elevated Hemangiomas: birth marks caused by begnin tumors of dermal blood capillaries

11. Accessories of the skin: Hair, Nails, and CutaneousGlands

12. Hair and Nails are composed of mostly dead keratinized cells. Skin (stratum corneum has soft keritin) Hair and Nails made of more compact, hard keritin, cross linked between keritin moelcules.

13. Cross section of a hair

14. Structures of hair

15. Basis of hair color and texture See page 199 Hair grows from the hair matrix just above the hair bulb. The hair bulb is near vascular connective tissue which provides hair with it’s nutrients.

16. Nail structure What are the Accessory Structures: Nails? – Nail body Dense mass of keratinized cells – Nail bed – Nail root – Cuticle (eponychium) – Lunula

18. Glands of the skin The skin has 5 types of Glands 1. Merocrine Sweat Glands 2. Apocrine Sweat Glands 3. Sebaceous Glands 4. Ceruminous glands 5. Mammary Glands

19. Sweat Glands Merocrine (eccrine) Most numerous Produces watery 99% perspiration for cooling 3-4X10 6 all over Palms, soles, forehead pH 4-6 Tubular gland with twisted coil Narrow lumen, opens at pore on skin Apocrine Occur in groin, anal, axilla, beard area. Produces thicker soln. with fatty acids Are scent glands Large lumen, opens to hair follicle

20. Sebaceous Glands Produce an oily secretion called SEBUM Flask shaped, located higher up in dermis Short ducts opening to hair follicles Keeps skin and hair from becoming dry (brushing hair spreads this) Lanolin in moisturizers is sheep sebum

21. Ceruminous Glands Found only in external ear canal Secretion combines with sebum &dead epithelial cells to make ear wax CERUMEN Waterproofs the ear canal and is anti-bacterial

22. Mammary Glands Milk producing glands in female breasts Are modified apocrine glands which produce richer secretions For summary see chart 6.2 on page 203

23. Skin Disorders see chart 6.3 What are the Effects of UV Radiation? – Beneficial effect – Activates synthesis of vitamin D 3 – Harmful effects Sun burn Wrinkles, premature aging Malignant melanoma Basal cell carcinoma

24. Skin Cancer Cancer: rapid mitotic division of cells caused by a trigger environmental, genetic Skin cancer: is caused by exposure to UV rays. There are three types named for tissue affected 1. Basal carcinoma: most common, easiest to remove. Appears as a red shiny bump that enlarges with depressed center

25. 2. Squamous Cell Carcinoma found usually on scalp, ears, lip, back of hands. Has red scaly appearance with concave center. High survival rate with early detection, will metastasize to lymph nodes highly lethal

26. 3. Malignant melanoma most deadly arises in melanocytes in moles. Fast to metastasize lethal without immediate treatment

27. Recognizing Malignant Melanoma A= Asymmetry B= Border irregularity C= Color (brown, black, tan, red, purple) D= Diameter (6mm)

28. Burns and Healing Burns: Leading cause in accidental death, death results from fluid loss and the toxic effect of eschar First degree: found in only epidermis, epidermis turns red, edema and pain, heals in a few days

29. Second degree: or partial-thickness burns due to damage only in top of dermis layers, has blisters can scar and takes about 2 weeks to heal Third degree: or total thickness burns, turns black, skin can only grow from sides of damaged area so grafts are needed, debridement must occur in 24 hours, then toxic

30. Healing and Repair on injury to skin What are the Four Stages in Skin Healing? 1. Inflammation Blood flow increases Phagocytes attracted 2. Scab formation 3. Cell division and migration 4. Scar formation

31. Bleeding occurs at the site of injury immediately after the injury, and mast cells in the region trigger an inflammatory response.

32. After several hours, a scab has formed and cells of the stratum germinativum are migrating along the edges of the wound. Phagocytic cells are removing debris, and more of these cells are arriving with the enhanced circulation in the area. Clotting around the edges of the affected area partially isolates the region.

33. One week after the injury, the scab has been undermined by epidermal cells migrating over the meshwork produced by fibroblast activity. Phagocytic activity around the site has almost ended, and the fibrin clot is disintegrating. After several weeks, the scab has been shed, and the epidermis is complete. A shallow depression marks the injury site, but fibroblasts in the dermis continue to create scar tissue that will gradually elevate the overlying epidermis