1. NATO Human Factors and Medicine Panel Activities Chemical, Biological, Radiological, Nuclear 2 October 2009 John F. Glenn, Ph.D. Human Factors and Medicine Panel Member

2. Human Factors and Medicine Panel 0908009F.pptx To optimize the health, safety, well-being, and performance of the human in operational environments. 2 Mission

3. Human Factors and Medicine Panel 0908009F.pptx Human Effectiveness Psychosocial, organizational, cultural, and cognitive aspects in military action Human Effectiveness Psychosocial, organizational, cultural, and cognitive aspects in military action Operational Medicine Aerospace, hyper/hypobaric, and military medicine necessary to ensure sustenance, health, safety, and survival of military personnel Operational Medicine Aerospace, hyper/hypobaric, and military medicine necessary to ensure sustenance, health, safety, and survival of military personnel Human Protection Human-centered research for optimizing physiological tolerance, protection, and survivability in adverse mission environments Human Protection Human-centered research for optimizing physiological tolerance, protection, and survivability in adverse mission environments Human System Integration Human-in-the-system analysis, design and evaluation, and experimentation Human System Integration Human-in-the-system analysis, design and evaluation, and experimentation 3 HFM Panel Scope

4. Human Factors and Medicine Panel 0908009F.pptx HFM-RTG-099Radiation Bio-Effects → Completed HFM-ET-078Risk Management of Exposure to Chemicals Under Operational Conditions → Ongoing HFM-ET-091Biological Countermeasures → HFM-RTG-186 HFM-ET-094Chemical Agent Protection (Non-Medical) → HFM-RTG-199 HFM-RTG-177Deployable Laboratory: Application of Emerging Nano and Bio-Technology HFM-RTG-186State-of-the-Art in Research on Medical Countermeasures Against Biological Agents HFM-RTG-189Bio-Effects and Standardization of Exposure Limits of Military Relevant High Energetic Electromagnetic Pulses (HEEP) HFM-RTG 199Integration of CBRN Physical Protective Measures to Lessen the Burden on Personnel Human Protection (CBRNE) 4

5. Human Factors and Medicine Panel 0908009F.pptx HFM-RTG-099 Radiation Bio-Effects Area Code: HPUK6 Taxonomy Code: B11.04 Chair: Germonpre (BEL) PfP Participation: No Classification: NATO Unclassified Objectives: Develop broad-spectrum bio-assessment tool(s). Establish underlying bases radiation injuries (at the molecular, cellular, and organ-system levels). Analyze injuries from combined exposures to radiation, chemicals, or other biological toxicants/agents. Develop safe and effective protocols for prevention and treatment of initial radiation injuries. Explore new molecular epidemiological approaches. 5

6. Human Factors and Medicine Panel 0908009F.pptx HFM-RTG-099 Radiation Bio-Effects Short Report: Meetings were held June 2005 (USA), June 2006 (SWE), June 2007 (CZE), and June 2008 (FRA). The group was divided into subgroups: 1.Radiobiology Mechanisms and Late Effects  Janiak (POL), Abend (DEU) 2.Radiation Injury Assessment and Biodosimetry  Wilkinson (CAN), Stricklin (SWE) 3.Prophylaxis and Therapy  Whitnall (USA), Herodin (FRA) 4.Combined Injuries and Treatment  Pellmar (USA), Stricklin (SWE) Planned deliverables include the identification of medical countermeasure options for ionizing radiation exposure; development and demonstration of prototypes of improved medical recording, biodosimetry, or radiation injury assessment tools, toxicology, and efficacy reports on selected protective/ therapeutic agents for radiation exposure. Follow-up activity is planned with FRA as a lead nation. 6

7. Human Factors and Medicine Panel 0908009F.pptx HFM-RTG-189 Bio-Effects and Standardization of Exposure Limits of Military Relevant High Energetic Electromagnetic Pulses (HEEP) Area Code: HPUK6 Taxonomy Code: B11.04 Chair: Szmigielski (POL), Klaunberg (USA) Meetings: November 2009 (USA) PfP Participation: Yes Classification: NATO Unclassified Objectives: Develop risk assessment code matrices for emerging technologies. Develop appropriate, safe maximum-permissible exposures. Develop improved methods of assessment of exposure. Develop exposure safety standards for millisecond and sub-millisecond radio frequency pulses. Establish experimental supporting protocols for sub-millisecond HEEP. Establish sufficient bioeffects databases to develop safe operational exposure limits for HEEP. 7

8. Human Factors and Medicine Panel 0908009F.pptx HFM-RTG-189 Bio-Effects and Standardization of Exposure Limits of Military Relevant High Energetic Electromagnetic Pulses (HEEP) Short Report: At the May 2009 (FRA) meeting, data was presented on: Ongoing standardization activities. Cellular bioeffects of HEEP. Decreased resistance of the cell membrane following exposure to a pulse (60 or 600 ns). This effect was recoverable over time. The proposed mechanism was the rearrangement of the lipid bilayer through creation of nanopores in the cell membrane. This is supported by the appearance of PS on the outside of the cell. Bioeffects of acute and chronic HPM. Increased place preference for a Faraday- protected side of a cage. Decreased rotarod performance and no increased BBB permeability following exposure. Increased GFAP expression 7 days post exposure (SR-X system) and 2 days post exposure (SR-S system). Chronic exposure (8 weeks, 5 days/week exposure) showed changes in survival and tumors. Complimentary aspects of both FRA and USA programs were noted, and potential collaboration is being pursued. 8

9. Human Factors and Medicine Panel 0908009F.pptx In Progress HFM-ET-091 Biological Countermeasures → HFM-RTG-186 State-of-the-Art in Research on Medical Countermeasures Against Biological Agents Objective: Review state-of-the-art research, development, test, and evaluation on medical countermeasures against biological agents. HFM-ET-094 Chemical Agent Protection (Non-Medical) → HFM-RTG-199 Integration of CBRN Physical Protective Measures to Lessen the Burden on Personnel Objectives: Define current and emerging systems for integrated protection. Assess existing operational concepts and determine key contributing technologies. Assess value and maturity of emerging, enabling technologies. Facilitate dialogue with operational and technical communities. Facilitate technical cooperation and data sharing. 9

10. Human Factors and Medicine Panel 0908009F.pptx In Progress HFM-RTG-177 Deployable Laboratory: Application of Emerging Nano and Bio-Technology Objective: Establish detailed design and capabilities guidelines for a deployable laboratory, designated equipment, review of emerging nano and bio-technologies and application to analytical and diagnostic procedures. HFM-ET-078 Risk Management of Exposure to Chemicals Under Operational Conditions Objective: Address the issue of health hazards resulting from exposure to chemicals, TICs, TIMs, or CW to develop a strategy as well as tools for risk management. 10