1. Microwave Radiometry Microwave Radiometry

2. The RTM-01-RES radiometer receives and evaluates the natural electromagnetic radiation (temperature) from the patient’s internal tissues at microwave frequencies RTM – Principles

3. Temperature Distribution

4. Venous and Arterial Blood Temperature Temperature ( o C) 31 32 33 34 35 36 37 carcinomas of upper outer quadrant carcinomas of upper outer quadrant carcinomas of inner quadrants carcinomas of inner quadrants ab c defghijk lateral thoracic vein  artery  internal mammary cancercancer

5. Growth Rate and Specific Heat Production of Breast Carcinomas Metabolic Heat Production of Cancer Tissue q * (10 -3 W/cm 3 ) Doubling Time of Tumor Volume (days) 10 70 20 30 40 50 60 0 200 300400500600700100 WITHOUT lymph node metastases WITH lymph node metastases 128 Breast Carcinomas T1 and T2

6. Heat transfer in mammary gland

7. Depth of penetration of tissue

8. Conductivity of normal and malignant tissues

9. Antennas` Field Dx Z ENERGY % Dx, cm Dy, cm Z, cm V, cm 3 201.451.2 0.8 1.4 301.71.61.22.6 402.121.64.5 502.5227.1 6032.4 10.6 703.42.83.221.2 803.83.24.343 904.246.2112.3 954.54.88.4273.7

10. RTM – 01 – RES Imaging System ItemsSpecifications Thermal abnormality (i.e. a lower or higher temperature) is detected at a depth of, cm 3 ‑ 5 (depending on water content tissue type) Accuracy of measuring the averaged internal temperature, when a temperature is 32 ‑ 38  C,  C  0,2 Time required for measuring internal temperature at a point, seconds 6 Antenna diameter, mm39 Accuracy of measuring the skin temperature,  C  0,2 Time required for measuring skin temperature at a point, when the temperature is 32 ‑ 38  C, seconds 1 Device mass, kg4 Power consumption, Watt5

11. The efficacy of the method is confirmed by clinical trials, which were carried out among more then 3500 patients RTM - Diagnosis

12. Breast Temperature Field Results of the measurements can be displayed in different modes

13. RTM-Diagnosis Software Data of the measured temperatures are automatically stored in the computers memory to be processed.

14. The green color represents the average temperature field of an examined organ Right MG Left MG Temperature(ºC): Minimum 32.8, Mean 33.8, Maximum 35.3 Isotherm step Breast Temperature Field

15. The red color represents a high temperature field of an examined organ Right MG Left MG Temperature(ºC): Minimum 32.8, Mean 33.8, Maximum 35.3 Isotherm step Breast Temperature Field

16. The blue color represents a lower than average normal temperature The blue color represents a lower than average normal temperature Right MG Left MG Temperature(ºC): Minimum 32.8, Mean 33.8, Maximum 35.3 Isotherm step Breast Temperature Field

17. Example: This is the temperature field of a healthy woman’s breasts. Temperature(ºC): Minimum 34.8, Mean 35.1, Maximum 35.4 Right MG Left MG Isotherm step Healthy Woman’s Field

18. Many diseases (such as cancer) are represented by high temperature areas in the internal temperature field. Temperature(ºC): Minimum 32.8, Mean 33.8, Maximum 35.3 Right MG Left MG Isotherm step Breast Temperature Field

19. The software analyses whether an examined patient has features of cancer. Sign A Sign ESign F Sign G Sign B Sign C Sign D Expert System

20. The results of the measurements may also be displayed as a thermogram. The fourth and the fifth points on the left breast are marked. Thermogram - Diagnosis right Mg left Mg Series 1 base point T1 Series 2 Series 3 Conventional signs Print… Help Close Show all seriesThermogram

21. In this case there is an extremely high possibility that the examined patient has left breast cancer Right Breast Left Breast Isotherm step Close object: Mark 1 Mark 2 Sign A Sign B Sign C Sign D Sign F Sign G Sign E right Mg left Mg Series 1 base point T1 base point T2 Series 2 Series 3 Conventional signs Print… Show all series Help Close

22. The RTM-01-RES is indispensable for the monitoring of treatment due to the fact that it is absolutely harmless. The RTM-01-RES is indispensable for the monitoring of treatment due to the fact that it is absolutely harmless. This is a sample of the positive dynamics which occur during the treatment of mastitis. This is a sample of the positive dynamics which occur during the treatment of mastitis. Patient B. (after treatment). Right Breast Left Breast Patient B. (before treatment). Right Breast Left Breast

23. Clinical diagnosis - both breasts have diffuse fibrocystic mastopathy, node neoplasm is not detected. X-ray - fibrocystic mastopathy with fibrous features. Puncture - erythrocytes, fat drops. During oncological processes thermal changes precede anatomical changes. The diagnostic method has a unique ability to detect cancer diseases at early stages, when the traditional methods can not detect diseases, which have just appeared. Patient K., 57 years old

24. Clinical Trials Results Number of Patients – 771 Cancer Patients – 101 (13%) Number of Patients – 771 Cancer Patients – 101 (13%) Number of Patients – 43 Cancer Patients – 35 (76%) Number of Patients – 43 Cancer Patients – 35 (76%) Number of Patients – 81 Cancer Patients – 48 (60%) Number of Patients – 81 Cancer Patients – 48 (60%) Number of Patients – 81 Cancer Patients – 48 (60%) Number of Patients – 81 Cancer Patients – 48 (60%)

25. №Diameter (см)N% Thermo positive Thermo negative Risk groupUncertain conclusions NNN%N%N% 1 No Tumors 299,21965,5620,7413,800 2 Less 1,3 см 1961052,6210,5526,3210,5 3 1,3 ≤D< 1,8 4514,22657,7613,31226,612,2 4 1,8 ≤D< 2,3 5818,33662,146,91627,623,4 5 2,3 ≤D< 2,6 4915,53979,624,1612,224,1 6 2,6 ≤D< 3,6 4213,33788,137,124,8Нет0 7 3,7 ≤D< 7 3711,73389,112,738,1Нет0 8 Infiltration Defuse Form 113,51090,9Нет0 019,1 9 No information 268,22284,627,72 Нет0 Итого 31610023273,42,68,25015,882,5 RTM Results