1. Organic compounds contain carbon and are found in living things. They usually contain C-H or C-C bonds. The organic compounds we study can be used in metabolic reactions.

2. Vitalism – a paradigm shift in biology Vitalism was the belief that living organisms and non-living organisms have different properties Called the “vitalistic element”, this was believed to distinguish living from non-living matter This theory was disproved by a chemist – Friedrich Woehler. He synthesized artificial urea by mixing cyanic acid and ammonium. This discovery was the first time an organic substance was made from inorganic material

3. Carbohydrates!

4. Glucose General formula: C 6 H 12 O 6 We count the carbons in clockwise direction, starting with the first carbon after the oxygen atom in the ring. This is the basic mono-saccharide (single-unit) hexose (6-carbon) sugar molecule that is used in respiration. It is a chemical store of energy. This is a diagram of beta- D-Glucose

5. Ribose General formula: C 5 H 10 O 5 We count the carbons in clockwise direction, starting with the first carbon after the oxygen atom in the ring. This is the basic mono-saccharide (single-unit) pentose (5-carbon) sugar molecule. It is found in RNA and a similar version in DNA.

6. What happens if you connect many monomers together, what do that look like?

9. Glycogen is an insoluble storage molecule in the liver. When blood glucose is high, the pancreas releases insulin, telling the liver to capture blood glucose and combine molecules of glucose to make the polysaccharide glycogen, through condensation reactions. This stores energy for later. When blood glucose drops, the hormone glucagon causes the glycogen to be broken down (hydrolysis reactions) to glucose and then released back into the blood. Liver from: http://en.wikipedia.org/wiki/File:Leber_Schaf.jpghttp://en.wikipedia.org/wiki/File:Leber_Schaf.jpg blood glucose too high blood glucose too low

10. Lactose Breastfeeding logo from: http://en.wikipedia.org/wiki/File:Breastfeeding-icon-med.svghttp://en.wikipedia.org/wiki/File:Breastfeeding-icon-med.svg Lactose is a disaccharide produced in mammal mothers. It consists of glucose and galactose and is easily digested by the lactase enzyme in the young animal’s digestive system. By producing a small disaccharide that can be broken down by lactase, the mother can provide her young with a source of energy that can be quickly digested after feeding and then readily used in respiration.

11. Lipids!

12. Fatty Acids & Glycerol Fatty acid chains can be of many lengths, extended by adding CH 2 units. They are an efficient store of energy and bond with glycerol (a simple sugar alcohol) to make triglycerides – lipids.

13. The different types of Fatty Acids

15. What are some uses of lipids in living things? Lipids are useful storage mechanisms because they are insoluble in water. If the human body stored glucose, which is soluble in water, what would happen to the cells as they stockpiled more and more glucose?

16. How does it all come together?

17. Calculating your BMI Formula One – for the civilized worldFormula two – for ‘murica (and Estonia) BMI = weight (kg)/[height (m) x height (m)] BMI = weight (lb)/ [height (in) x height (in)] x 703 Example 1 – Person who is 1.70m tall and weighs 58 kg. BMI = 58/(1.7x1.7) BMI = 20.1 Example 2 – Person who is 5’10” and weighs 235 lb. BMI = 235/(70x70) x 703 BMI = 33.7

18. But what does that mean for you? Take the time to calculate your own BMI using the formula. Use this as guidance for how you structure your diet.

19. Carbohydrates vs Lipids for energy storage

21. ribose glucose amino acid (glycine) glycerol

22. Proteins!

23. Amino Group (-NH 2 ) Carboxylic Acid Group (-COOH) A generalized amino acid The amino group is one of the reasons why nitrogen is an important element in living things. The carboxylic acid group contains an oxygen double-bonded to the carbon and a hydroxyl group (-OH) that can be lost to form new bonds. The basic structure of the amino acids is common. There are 22 different protein-making amino acids, though only 20 are coded for in genetic code. Each has its own unique R-group. Some are polar, others non-polar and their different properties determine their interactions and the shape of the final protein.

24. Methionine: an amino acid Methionine is an important amino acid as it is coded by the START codon in mRNA (AUG). This means that is is the first amino acid in all polypeptide chains as it is the first produced in transcription in the ribosomes. Although methionine (Met) has quite a large R-group, we can still identify the amino group and carboxylic acid group on the amino acid. Sulphur forms strong bonds (disulphide bridges) with other S-containing amino acids. http://en.wikipedia.org/wiki/Methionine The simplest amino acid is glycine, with H in the R-group position.

25. Animation: http://is.gd/PeptideBondhttp://is.gd/PeptideBond

26. Animation: http://is.gd/PeptideBondhttp://is.gd/PeptideBond

29. Protein Structure Proteins have four main levels to their structure: Primary protein structure: the sequence of amino acids within the protein; this sequence determines the three- dimensional shape Secondary protein structure: repetitive shapes of either a helix (a spiral staircase shape) or a pleated sheet, such as in spider silk Tertiary structure: a shape often described as globular, such as in enzymes Quaternary: two or more polypeptides combined together to make a single functional protein, such as in hemoglobin

32. ProteinFunction RubiscoEnzyme that catalyzes the first reaction of the carbon fixing reactions of photosynthesis InsulinHormone produced by the pancreas that results in a decrease of blood sugar levels ImmunoglobulinAntibody that recognizes an antigen as a part of the immune response RhodopsinPigment found in the retina of the eye that is particularly useful in low light conditions CollagenMain protein component of connective tissue, which is abundant in skin, tendons, and ligaments Spider silkFibrous protein spun by spiders for making webs, drop lines, nest building and other uses

33. Denaturation can occur to proteins when they are exposed to high temperatures or extreme pH. Denaturation causes a protein to lose its shape, and therefore lose its properties. High temperature causes bonds to break from extra energy High pH causes hydrogen bonds to break, causing loss of structure

35. this one (glycine)

36. Condensation reactions make bonds. Hydrolysis bonds break these bonds. Watch these three animations and make a generalisation about the processes: -function, roles of enzymes, roles of water http://is.gd/PeptideBond http://is.gd/MaltoseGIF http://is.gd/TriglycerideGIF