1. Chronomics: circadian effects of magnetic storms in rabbits' circulation and transannual variations? Sergei Chibisov*, Germaine Cornélissen, Franz Halberg Материалы третьей Межд. конф. «Болезни цивилизации в аспекте учения В.И.Вернадского» 10-12 октября 2005 г., С. 416-418

2. Background Biological variables sampled mostly daily with variable density (from half-hourly sampling to once or twice a day) for 6 or more (up to 36) years longitudinally, on the same individual, exhibit reproducibly changing chronomes (structures in time). Biological variables sampled mostly daily with variable density (from half-hourly sampling to once or twice a day) for 6 or more (up to 36) years longitudinally, on the same individual, exhibit reproducibly changing chronomes (structures in time).

3. Background Chronomes consist of Chronomes consist of 1. probabilistic and other chaos, 2. trends and 3. a broad spectral element.

4. Background Components in the spectral region of about 1.3 years correspond roughly to the periodicity of about 1.3- and/or about 1.6- year length in the solar wind, herein called the transyear. Components in the spectral region of about 1.3 years correspond roughly to the periodicity of about 1.3- and/or about 1.6- year length in the solar wind, herein called the transyear.

5. Background Transyears are defined as spectral components with 95% confidence intervals for the period between 1 and 2 years that overlap neither of these two trial periods, nor one another when there is more than one transyear (such as in human urinary 17-ketosteroid excretion). Transyears are defined as spectral components with 95% confidence intervals for the period between 1 and 2 years that overlap neither of these two trial periods, nor one another when there is more than one transyear (such as in human urinary 17-ketosteroid excretion).

6. Background Thus, there can be two or more distinct components in the about-yearly region of biological spectra, one or several transyears and/or another component of about 1-year length. Thus, there can be two or more distinct components in the about-yearly region of biological spectra, one or several transyears and/or another component of about 1-year length.

7. Methods The left and right ventricular pressures of rabbits were measured at intervals around the clock in different seasons. The left and right ventricular pressures of rabbits were measured at intervals around the clock in different seasons. The data were analyzed by linear-nonlinear rhythmometry for an assessment of any circadian, circannual and transyearly variations. The data were analyzed by linear-nonlinear rhythmometry for an assessment of any circadian, circannual and transyearly variations.

8. Methods We here summarize two kinds of information, one event-related, the other cycle-related. We here summarize two kinds of information, one event-related, the other cycle-related. The event-related findings consist of the statistically significant alteration of the circadian acrophase of intracardiac pressure by magnetic storms. The event-related findings consist of the statistically significant alteration of the circadian acrophase of intracardiac pressure by magnetic storms. The cycle-related findings consist of the detection of a transannual vs. circannual cycle in intracardiac pressure of different comparable groups of rabbits sampled in four seasons under comparable conditions in the laboratory. The cycle-related findings consist of the detection of a transannual vs. circannual cycle in intracardiac pressure of different comparable groups of rabbits sampled in four seasons under comparable conditions in the laboratory.

9. Results The circadian acrophase differs with statistical significance, with a near-antiphase during a 3-day span with stormy geomagnetic activity versus similar spans during relatively quiet conditions in 3 other seasons as well as in the same season 4 years earlier, when data collected over a single day also differ in terms of MESOR and circadian amplitude. The circadian acrophase differs with statistical significance, with a near-antiphase during a 3-day span with stormy geomagnetic activity versus similar spans during relatively quiet conditions in 3 other seasons as well as in the same season 4 years earlier, when data collected over a single day also differ in terms of MESOR and circadian amplitude.

14. Results Differences in MESOR and circadian amplitude from season to season are part of an about- yearly variation. Differences in MESOR and circadian amplitude from season to season are part of an about- yearly variation. Acrophases are numerically more tightly clustered at the 1.3-year than at the 1.0-year trial period, covering 36˚ vs. 46˚, respectively (360˚ being equated to each of these periods). Acrophases are numerically more tightly clustered at the 1.3-year than at the 1.0-year trial period, covering 36˚ vs. 46˚, respectively (360˚ being equated to each of these periods).

15. Rhythmometric Summaries Trial period (years) Variable -------- 1.0 ------- ------- 1.3 ------- MESOR ± SE PR(%)Amplitude Acrophase PR(%) Amplitude ± SE Acrophase ± SE MAP-LV 119.5 ± 1.4 1215.1 ± 1.9 -6° ± 7 1216.5 ± 1.8 -324° ± 9 SBP-LV 199.3 ± 1.3 912.6 ± 1.9 -22 ° ± 8 610.8 ± 1.7 -336° ± 13 MAP-RV23.0 ± 0.2 92.0 ± 0.3 -348 ° ± 9 92.5 ± 0.3 -309° ± 8 SBP-RV42.6 ± 0.4 103.8 ± 0.5 -336 ° ± 8 104.9 ± 0.6 -300° ± 7 P<0.001 in all cases for zero-amplitude test of 1.0 and 1.3-year components.

16. Discussion Data collected over several years will be needed to distinguish between the circannual and transannual components, notably since the tighter clustering of acrophases of the transyear needs to be qualified by a larger standard error as compared to that of the calendar year. Data collected over several years will be needed to distinguish between the circannual and transannual components, notably since the tighter clustering of acrophases of the transyear needs to be qualified by a larger standard error as compared to that of the calendar year.

17. Discussion Associations of magnetic activity with the rabbits' circulation at the circadian and transannual frequencies have their precedent in the circulation of babies and in human adults' blood pressure and heart rate studied longitudinally by studies of cross-spectral coherence. Associations of magnetic activity with the rabbits' circulation at the circadian and transannual frequencies have their precedent in the circulation of babies and in human adults' blood pressure and heart rate studied longitudinally by studies of cross-spectral coherence. The results await scrutiny by time-varying coherence and phase synchronization. The results await scrutiny by time-varying coherence and phase synchronization.

18. Conclusions The solar wind now and in an evolutionary past competed with the seasons in the circulation of rabbits and humans. The solar wind now and in an evolutionary past competed with the seasons in the circulation of rabbits and humans. Effects of the cosmos can be quantified by chronomics. Effects of the cosmos can be quantified by chronomics.