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Published byCharla Bruce Modified over 9 years ago
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AWESOME LECTURE#2
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Microfluidics + integrated circuit can control cells and chemical compounds.
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MICROFLUID + INTEGRATED CIRCUIT =
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Overview…
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What are microfluids?
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Overview… What are microfluids? Lab on a Chip (control)
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Overview… What are microfluids? Lab on a Chip (control) Tests & Applications
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SMALL FLUIDS!
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Channel < 1 mm in length
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SMALL FLUIDS! Channel < 1 mm in length Examples:
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SMALL FLUIDS! Channel < 1 mm in length Examples:
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SMALL FLUIDS! Channel < 1 mm in length Examples:
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SMALL FLUIDS! Channel < 1 mm in length Examples:
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SMALL FLUIDS! Channel < 1 mm in length Examples:
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Interesting properties…
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Reynolds Number (flow)
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Interesting properties… Reynolds Number (flow) Re = L V avg ρ/μ
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Interesting properties… Reynolds Number (flow) Re = L V avg ρ/μ ▪ L = most relevant length
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Interesting properties… Reynolds Number (flow) Re = L V avg ρ/μ ▪ L = most relevant length ▪ ρ = fluid density
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Interesting properties… Reynolds Number (flow) Re = L V avg ρ/μ ▪ L = most relevant length ▪ ρ = fluid density ▪ μ = viscosity
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Interesting properties… Reynolds Number (flow) Re = L V avg ρ/μ ▪ L = most relevant length ▪ ρ = fluid density ▪ μ = viscosity Re < 100
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Interesting properties… Reynolds Number (flow) Re = L V avg ρ/μ ▪ L = most relevant length ▪ ρ = fluid density ▪ μ = viscosity Re < 100 Re > 2000
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Types of Flow
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Pressure Driven Flow
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Types of Flow Pressure Driven Flow http://faculty.washington.edu/yagerp/microfluidicstutorial/tutorialhome.htm http://faculty.washington.edu/yagerp/microfluidicstutorial/tutorialhome.htm
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Types of Flow Electrokinetic Flow
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Types of Flow Electrokinetic Flow http://faculty.washington.edu/yagerp/microfluidicstutorial/tutorialhome.htm http://faculty.washington.edu/yagerp/microfluidicstutorial/tutorialhome.htm
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What is it?
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Programmable chip + microfluidics chamber
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What is it? Programmable chip + microfluidics chamber Why do we need it?
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What is it? Programmable chip + microfluidics chamber Why do we need it? Larger quantities
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What is it? Programmable chip + microfluidics chamber Why do we need it? Larger quantities Smaller objects
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What is it? Programmable chip + microfluidics chamber Why do we need it? Larger quantities Smaller objects DNA, living cells, droplets of chemical compounds
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But how does it work?
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DIELECTROPHORESIS (DEP)
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But how does it work? DIELECTROPHORESIS (DEP) Non-uniform field induced dipole
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But how does it work? DIELECTROPHORESIS (DEP) Non-uniform field induced dipole Apply local e-field
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But how does it work? DIELECTROPHORESIS (DEP) Non-uniform field induced dipole Apply local e-field Different dielectric constant force
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F DEP = 2πε m a 3 CM(ω) Grad(E rms 2 )
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Clausius-Mossoti factor
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F DEP = 2πε m a 3 CM(ω) Grad(E rms 2 ) Clausius-Mossoti factor CM(ω) = Re [ (ε p - ε m ) / (ε p + 2 ε m )]
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F DEP = 2πε m a 3 CM(ω) Grad(E rms 2 ) Clausius-Mossoti factor CM(ω) = Re [ (ε p - ε m ) / (ε p + 2 ε m )] ▪ CM(ω) < 0 nDEP
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F DEP = 2πε m a 3 CM(ω) Grad(E rms 2 ) Clausius-Mossoti factor CM(ω) = Re [ (ε p - ε m ) / (ε p + 2 ε m )] ▪ CM(ω) < 0 nDEP ▪ CM(ω) > 0 pDEP
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http://www.blazelabs.com/pics/emep.gif
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Voltage…
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AC fields
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Voltage… AC fields No ion shielding
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Voltage… AC fields No ion shielding Less harmful
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Voltage… AC fields No ion shielding Less harmful 5V CMOS process
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Voltage… AC fields No ion shielding Less harmful 5V CMOS process Lower noise
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Voltage… AC fields No ion shielding Less harmful 5V CMOS process Lower noise Less heat
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Yeast
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Programming of large numbers of cells
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Yeast Programming of large numbers of cells Assembly of tissue
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Mammalian cells work too!
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Rat alveolar macrophages
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Mammalian cells work too! Rat alveolar macrophages
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Mammalian cells work too! Rat alveolar macrophages Presumably human cells work too!
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APPLICATIONS!
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Programmable chemistry
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APPLICATIONS! Programmable chemistry Tissue assembly
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APPLICATIONS! Programmable chemistry Tissue assembly Art?
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APPLICATIONS! Programmable chemistry Tissue assembly Art? … no one will be able to see it…
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Microfluids
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ARE
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Microfluids ARE very useful when combined with an integrated circuit.
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