1. Green Chemicals from Our Oceans Combat bacteria in a new way Marilyn Bruno, Ph.D., J.D., CEO www.aequorinc.com

2. BIOFILM Forms everywhere, quickly E.g. on a titanium plate within 30 seconds after sterilization. Impenetrable, protecting underlying bacteria Chemicals in biofilm’s top layers neutralize even the strongest biocides Disperses Becomes airborne/waterborne (e.g. Legionella) Diagram of how biofilm builds in stages: https://en.wikipedia.org/wiki/Biofilm

3. We’re Losing the War on Bacteria BIOFILM PROTECTS BACTERIA FROM Physical remedies – scraping, sterilization, heat Biocides (germicides, antimicrobials, antiseptics) Human immune system Antibiotics OVERUSE OF INEFFECTIVE REMEDIES: Toxic load on ecosystems Trigger bacterial resistance – e.g. MRSA

4. Biofilm Impacts on Industry Microfouling - contamination, corrosion, scale, slime Increases costs, reduces yields Clogs RO filters used in desalination, water treatment Reduces life of capital equipment Contaminates inert, nano, organic surfaces Reduces algae cultivation yields: bioreactors and open pond Reduces outputs of solar panels, wind turbines, etc. Macrofouling – increases fuel consumption, emissions Attachment of barnacles, mussels, algae – Water intake pipes for all power plant cooling towers – Hulls of all the ships at sea – Underwater structures, pipelines, equipment Loss of profits for emerging industries – Aquaculture: nets clogged so badly, fish need antibiotics

5. Biofilm Impacts on Healthcare All surfaces contaminated – from bedrails to devices CDC associates biofilm with – 80% of all chronic bacterial infections – 14% Intensive Care Unit deaths – 90% Hospital Acquired Infections (HAIs) – EVERY bacteria on the lists of Pandemic threats (cholera, pneumonia, Listeria, E.coli, Salmonella, T.B., flu, Legionella, meningitis, plague, etc.) Bioterrorism (anthrax, botulism) Drug-resistance (MRSA, MDR-TB) BIOFILM is now a global security issue

6. Biofilm in Space More virulent than on Earth – Because of extreme temperatures, radiation, vacuum Fouls equipment – Satellite optical sensors – so thick, it is skewing readings – Probes Impacts astronaut health – Contaminates all systems: water, air, food Toxic biocides – don’t work – can’t be safely disposed of NASA calls biofilm the #1 impediment to long duration manned space travel

7. Aequor’s Discoveries Discovered Platform: novel marine organisms Novel chemical entities Primary molecule FROM THE SEA – Founder Cynthia Burzell hypothesized that all surfaces would be fouled unless some natural mechanism inhibited the attachment of foulers

8. Primary Molecule Validation Removes 99.99% existing biofilms - Lonza: “Nothing else known can do this at non-lethal doses” Inhibits biofilm formation > 95% at 48 hours Inhibits attachment of marine foulers >92% Is non-toxic, per Ames test, brine shrimp larvae assay Staphylococcus aureus untreated forms thick biofilm S.Aureus with Aequor semi-purified lead compound COMPARE WITH S.aureus with Penicillin at 1,000 x dose tolerated by humans

9. Value Proposition FOR CUSTOMERS : “Greening” their bottom line Replace toxic biocides; “bio-boost” performance of current remedies at lower concentrations Save time, manpower and money – and lives FOR CLEANTECH: Antifouling reduces drag Lower fuel, gas emissions by 50%; downtime Raise yields Increase profitability, life of capital equipment

10. Company Traction Portfolio of novel chemicals IP estate managed by K&L Gates Team Aequor Cynthia Burzell, Ph.D. Microbiology – Founder, President TechAmerica’s Researcher of the Year Marilyn Bruno, Ph.D., J.D., CEO 35+ years in business. Woman Entrepreneur of the Year Jozsef Gulyas, Ph.D. – world expert - chemical synthesis + 12 seasoned Advisors, including Toshiyasu Nagae – Industry specialist F ormer President, Union Carbide/Dow – Japan Awards

11. WHY AEQUOR? WHY NOW? Validations Product – Unique, disruptive, superior to competition Pain Market Size Customers Go-to-Market Plan Business model, Pricing Company traction Triple Bottom Line: Profit, People, Planet mbruno@aequorinc.commbruno@aequorinc.com www.aequorinc.com