1. Chapter 13.2 Ribosomes and Protein Synthesis

2. Key Questions What is the genetic code and how is it read?
What role does the ribosome play in assembling proteins?
What is the “central dogma” of molecular biology?

3. Ribosome
rRNA
Protein Assembly

4. mRNA
Codon– 3 mRNA (genetic code) DNA  mRNA to the ribosome

5. The Steps of Translation
mRNA leaves the nucleus  ribosome
AUG-start codon-enters the ribosome
tRNA brings amino acid to the ribosome
Codon and anticodon attach together
Amino acids on the tRNA bind together—peptide bond
tRNA leaves, mRNA shifts down, another tRNA attaches, process repeats until it gets to a stop codon. Forms polypeptide chain (protein)

6. Animations
#1 #2 #3

7. Central Dogma
DNA  RNA  Protein

8. Making Proteins #1 | #2 | #3 | #4 | #5 Amino Acids AUG– Methionine
DNA T A C A A C G T A C G A A C T
mRNA A U G | U U G | C A U | G C U | U G A
#1 | #2 | #3 | #4 | #5
Amino Acids
AUG– Methionine
UUG- Leucine
CAU- Histidine
GCU- Alanine
UGA- Stop