1. Radiopharmaceutical Production FDG Synthesizers STOP

2. Introduction This module provides basic information on FDG production chemistry. These links will lead you to presentations about the synthesis of FDG in general, how the commercial synthesizers work and some common problems with FDG synthesis. The next slide gives an overview of the commercially available synthesizers. Content Overview of FDG synthesis.Overview of FDG synthesis. How Synthesizers work Troubleshooting Guide for FDG SynthesisTroubleshooting Guide for FDG Synthesis Commercial Synthesizers STOP

3. Introduction This module provides an overview of the commercially available FDG synthesis units. In all cases, please follow the links to the company website to get the latest information on each synthesizer Content ACSI BIOSCAN GE HEALTHCARE IBA Molecular KIRAMS RAYTEST SIEMENS SUMITOMO STOP

4. Radiopharmaceutical Production FDG Synthesis Units Content ACSI BIOSCAN GE HEALTHCARE IBA Molecular KIRAMS RAYTEST SIEMENS SUMITOMO STOP ACSI WEB PAGE ACSIACSI The Advanced FDG Carousel Dual Synthesis module is a fully automated, single-purpose device that produces sterile, pyrogen- free Fluoro-Deoxy-Glucose (FDG) suitable for human use. The only user intervention required is loading of the starting kits, and removal of the final product. A Lookout based user interface keeps the user informed of the status of the production. The sequence and length of each process step can be changed easily by editing an Excel spreadsheet.

5. Radiopharmaceutical Production FDG Synthesis Units Content ACSI BIOSCAN GE HEALTHCARE IBA Molecular KIRAMS RAYTEST SIEMENS SUMITOMO STOP Bioscan FDG-Plus Synthesizer  Lower capital costs compared to other systems  Lower run costs compared to other systems  Increased reliability  True "infinite run" capability on a single box  Extremely small size - two units will fit into a single mini hotcell  Improved diagnostics  Improved self-testing  Based on Bioscan’s years of experience in demanding commercial FDG labs WEB PAGE BIOSCANBIOSCAN

6. Radiopharmaceutical Production FDG Synthesis Units Content ACSI BIOSCAN GE HEALTHCARE IBA Molecular KIRAMS RAYTEST SIEMENS SUMITOMO STOP GE Healthcare FDG Modules TRACERlab ™ offers a complete series of synthesizers for small to medium scale production of PET tracers, addressing both clinical and research needs. FASTlab™, a automated PET radiochemistry synthesis platform for FDG. FASTlab offers the versatility and flexibility to develop and produce additional fluoride-based tracers WEB PAGE GE HEALTHCAREGE HEALTHCARE Synthesizer Fact sheet

7. Radiopharmaceutical Production FDG Synthesis Units Content ACSI BIOSCAN GE HEALTHCARE IBA Molecular KIRAMS RAYTEST SIEMENS SUMITOMO STOP IBA Molecular Products | Synthera Synthera® is designed to accommodate a wide range of radiochemistries. Modules can be interconnected in series to implement complex processes. Creation of different tracers only requires changing the IFP™ model. Syntheses are reproduceable. Integrated Fluidic Processor (IFP™) is an innovative solution for the automation of a multitude of predefined syntheses while offering the benefit of a disposable system. WEB PAGE IBA MolecularIBA Molecular

8. Radiopharmaceutical Production FDG Synthesis Units Content ACSI BIOSCAN GE HEALTHCARE IBA Molecular KIRAMS RAYTEST SIEMENS SUMITOMO STOP Kirams KIRAMS 215-4, Gomgneung-Dong, Nowon-Gu, Seoul, 139-706, Korea Tel : 82-2-970-1331 Fax : 82-2-970-1332 WEB PAGE KIRAMSKIRAMS Well established technology can guarantee high yield and reproducibility. Easy maintenance due to enough rear access. Customizable software can make: Flexible synthesis. Easy application. Data tracking is possible in real-time. Automatic graphical reporting of collected data

9. Radiopharmaceutical Production FDG Synthesis Units Content ACSI BIOSCAN GE HEALTHCARE IBA Molecular KIRAMS RAYTEST SIEMENS SUMITOMO STOP Raytest very compact fully visible process ultra fast reactor heating / cooling magnetic stirrer mixing system tube lifting system cartridge product purification built-in vacuum pump built-in pressure control on-line process control interactive process diagram fully automatic operation reported manual intervention online/offline process development interface GLP / GMP / 21CFR part 11 compliant highest reliability highest yield ( >55%) acid or base hydrolysis possible WEB PAGE RaytestRaytest

10. Radiopharmaceutical Production FDG Synthesis Units Content ACSI BIOSCAN GE HEALTHCARE IBA Molecular KIRAMS RAYTEST SIEMENS SUMITOMO STOP Siemens WEB PAGE SIEMENSSIEMENS Typical System Performance Yield of synthesis (decay corrected to EOB) > 65% Set-up time < 20 minutes Synthesis time ≤ 45 minutes Clean up time < 35 minutes Dimensions Width 24 in (61 cm) Depth 14 in (36 cm) Height 19 in (48 cm) Weight 150 lbs (68 kg) Explora is registered trademark of Siemens Medical Solutions USA, Inc. See a Powerpoint presentation about the Siemens Synthesizers

11. Radiopharmaceutical Production FDG Synthesis Units Content ACSI BIOSCAN GE HEALTHCARE IBA Molecular KIRAMS RAYTEST SIEMENS SUMITOMO STOP Sumitomo WEB PAGE SUMITOMOSUMITOMO Our 18 FDG system is systematized from synthesis module and official approval quality- inspection module and administration dosage module in the lead cover,for radiation exposure reduction

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