1. New Treatments

2. New drug treatments Chronotherapy Lung cancer vaccine Summary

3. New drug treatments -Royal Marsden Hospital (London) -Specific mutations -Sophie (11y/o) → success

4. Chronotherapy -Biological clock -Circadian rhythms -Signs + symptoms change → Chronotherapy -Treatments at most optimal time

5. Chronotherapy -Inconvenients: - Best time = night (often) - Mechanisms not well known -P53 protein: - tumour suppressor - helps prevent mutation -Personalised treatment

6. Lung cancer vaccine

7. Introduction -Center of Molecular Immunology -1 st lung cancer vaccine -Cimavax -Not a cure: - survival of patient - helps immune system - therapeutic vaccine

8. Advantages -Cheap to produce + store -Few side effects - nausea - chills - fever

9. How does it work ? Cancer stimulates production EGF Stimulates growth of cells Tumors multiply + grow uncontrollably EGF : epidermal growth factor → body creates antibodies

10. Research -Chemotherapy + ½ vaccine -Trials showed: - More antibodies - Lived longer - Reduces cancer symptoms

11. This vaccine could be used for other types of cancer

12. Conclusion -A lot of new treatments -More and more effective -Cancer has to be found early -However, treatments more effective on some people than on others