1. ENZYMES http://www.biologie.uni-hamburg.de/b-online/library/cat-removed/enzyme_.gif

2. Enzymes are proteins Chemical reactions need help to get started. Ex: A fire needs a match to get it started. The reactants (what you start with) need help to carry out the chemical reaction to develop the products http://www.chuckwagondiner.com/art/matches.jpg http://plato.acadiau.ca/COURSES/comm/g5/Fire_Animation.gif

3. ______________ to get a chemical reaction _______________ = ________________________ Image from: Pearson Education Inc, publishing as Pearson Prentice Hall. All rights reserved ACTIVATION ENERGY REACTANTS PRODUCTS ACTIVATION ENERGY Energy required STARTED

4. Exergonic Reactions Free energy Progress of the reaction ∆G < O EAEA Figure 8.14 A B C D Reactants A C D B Transition state A B CD Products

5. ___________ HELP CHEMICAL REACTIONS _______________ by ____________ the ___________________________to get a chemical reaction started. Image from: Pearson Education Inc, publishing as Pearson Prentice Hall. All rights reserved DECREASING Enzymes ACTIVATION ENERGY required HAPPEN FASTER

6. Progress of the reaction Products Course of reaction without enzyme Reactants Course of reaction with enzyme EAEA without enzyme E A with enzyme is lower ∆G is unaffected by enzyme Free energy Figure 8.15

7. PROTEINS CAN BE ENZYMES SUBSTRATE ENZYME-SUBSTRATE COMPLEX PRODUCTS ENZYME Unchanged & Reusable ENZYME Image modified from: http://www.biologie.uni-hamburg.de/b-online/library/cat-removed/enzyme_.gif Arrow: http://www.gifanimations.com/action/ImageDisplay/1/2/11/next ACTIVE SITE

8. ENZYMES _____ like a _______________ to only _________of _________. Enzymes are ___________ by the reaction and ___________ LOCK AND KEY REUSABLE UNCHANGED FIT ONE KINDSUBSTRATE http://www.grand-illusions.com/images/articles/toyshop/trick_lock/mainimage.jpg

9. FACTORS THAT AFFECT ENZYME ACTIVITY __________ & ______________ Conditions that are TOO ACIDIC or TOO HOT cause proteins to ________ or _________ pH temperature UNWIND DENATURE http://www.desktopfotos.de/Downloads/melt_cd.jpghttp://www.nealbrownstudio.com/adm/photo/163_nb_fried_egg.jpg See a movie Choose narrated

10. Progress of the reaction Products Course of reaction without enzyme Reactants Course of reaction with enzyme EAEA without enzyme E A with enzyme is lower ∆G is unaffected by enzyme Free energy Figure 8.15