1. Varian 920-LC Integrated Analytical HPLC

2. Varian 920-LC What Is It? Compact, stylish automated analytical HPLC
Pre-plumbed and factory tested for the highest confidence
Single cable communications
Each system comes with solvent delivery system, autosampler and either UV Vis or PDA detector
Options of a second Fl or RI detector and column heater
Virtually pulse-free dual piston pump
Does not require a pulse damper
State-of-the-art low pressure quaternary gradient module with built-in degasser

3. Varian 920-LC What Is It? Autosampler with cooling option
Synchronised injection for outstanding retention time reproducibility
Compatible with 200 x 2 mL HPLC vials or 3 microplates
Either sensitive dual l UV-Vis or PDA detector
Optional second detector - fluorescence or RI
High precision (<0.15 °C) dual column heater available
Low delay solvent pre-heater for improved heat transfer
Optional column switching and electric injection valve
NEW improved instrument interface on GalaxieTM software

4. Varian 920-LC Silver Bullets
Fast LC with superb performance optimised for sub 3 mm columns
Improved throughput without compromising robustness
Pulse-free solvent delivery
No need for a pulse damper
High sensitivity detection
Full system level computer controlled AIQ (validation)

5. Varian 920-LC Fast LC Phenones
0.1
0.2
0.3
0.4
0.6
0.5
0.7
0.8
0.9
1.0
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
mAU
RT [min]
100 90 80 70 60
110 40 30 50 20 10
Conditions
Mobile Phase: Water Acetonitrile Gradient
Detection: UV Detection
Temperature: 60°C
Flow-Rate: 1,6mL/min
Column: Varian Ultra 3um 50x2,0mm
acetophenone
Propiophenone
valerophenone
benzophenone
hexanophenone
heptophenone
octanophenone

6. Varian 920-LC Fast LC PAHs

7. Varian 920-LC Fast LC Performance
Dual piston quaternary pump produces fast gradients – even at 200 mL/min
Virtually pulse-free pumping without pulse damper
Outstanding gradient compositional accuracy give retention time precision at the <1% level
Built-in vacuum degas maintains pump prime and enhanced injection reliability
Accurate flow from 0.1 to 10 mL/min for 2 to 4.6 mm columns
Overlay of 10 chromatograms
10% steps at 1 mL/min

8. Varian 920-LC Autosampler
Needle-in-flow path geometry for low carry-over (<0.01%)
Typical inj precision (< 0.3% at 10 mL)
Optimized flow paths for fast injection turn-around
Synchronised injection for best RT reproducibility
Programmable wash setting for low carry-over
Injection volumes from 1 uL to 50 mL
Cooled option available

9. Varian 920-LC Superb Washout
125 µg/mL Caffeine
Blank injection <0.01% carryover

10. 920-LC Autosampler How Does it Work?

11. Varian 920-LC Injection Synchronization

12. Sensitive UV-Vis Detectors
Typical Agilent VWD S/N ~ 25
Typical Varian 920-LC UV Vis S/N ~ 38

13. Varian 920-LC Fluorescence Detector
Sensitive Fluorescence detector (S/N > 600 Raman H2O peak baseline method)
Time programmable l for increase sensitivity
Automatic l validation with built-in Hg lamp
Low 12 mL dead volume flowcell for improved chromatography

14. Heated Column Compartment
Temperature range from ambient + 10 °C up to 65 °C
Temperature reproducibility °C
Ensures excellent analytical reproducibility
Uses a low delay volume pre-heater for efficient heat transfer to mobile phase
Spacious column compartment easily accommodates 2 x 250 mm columns
Option with electrically actuated column switching valve and injection valve

15. Outstanding Stability

16. System Reproducibility of 50 Injections
Reproducibility <0.8% over 50 injections and 12 hours

17. Varian 920-LC Software Usability
User friendly GalaxieTM software
Simplified, modern, consistent Instrument interface
Modular 11 pages
920-LC 4 pages!!
One page real-time status and chromatogram
Advanced integration and calibration
New IMS capabilities
Automated instrument validation
Reduces downtime and operating costs
Fusion AE

18. Varian 920-LC AIQ (Validation)
AIQ (Analytical Instrument Qualification)
Fully PC controlled IQ and OQ (not PQ)
Puts the Varian 920-LC at the forefront of regulated capabilities
Consistent, reproducible methodology
Includes pumps, autosampler, detectors, column heater
Chargeable option
Fully documented

19. Varian 920-LC Ordering Matrix
pump
inject
detector
Oven
Detector 2
option
Options
Modular Isocratic
210-LC 10mL
Manual
325
PDA, RI, ELSD
Isocratic
Dual piston pump 10 mL head
Auto
Dual l UV/Vis
Opt
FL, RI
ELSD
Gradient
Quat, Grad, Degas
ELSD opt
High Performance Gradient
Auto cooled
Development
PDA
Std
Research

20. Varian 920-LC Target Markets
Strong historical position for Varian in analytical
Varian has the leading range of analytical technologies: spectroscopy, chromatography including consumables, data and services
Target Users
Environmental
Industrial
Generic Pharmaceutical *
Academia and Biotech
Same (but wider) target groups with a stronger product offering
*40% of Regulated Pharma has significant competitive barriers due to installed software base

21. Varian 920-LC Silver Bullets
Fast LC with superb performance optimised for sub 3 µm columns
Improved throughput without compromising robustness
Pulse-free solvent delivery
No need for a pulse damper
High sensitivity detection
Full system level computer controlled AIQ (validation)

22. Varian 920-LC Integrated Analytical HPLC