1. Abby El-Shafei Dr. Penny Asbell Ophthalmology Dept. Mount Sinai School of Medicine

2. Corneal Refractive Therapy (CRT) CRT is a method for temporarily correcting Myopia through lenses that are worn overnight to reshape the cornea Allows users to forgo glasses or contacts the next morning

3. Myopia “Nearsightedness” is a condition where a person cannot see distant objects clearly without glasses This results from spending a lot of time on computers, watching television, and reading books Corneal Epithelium Layer of cells that cover the surface of the cornea

4. Flurophotometry A useful clinical method that measures the levels of fluorescein in the eye to determine corneal epithelial permeability in which the Fluorotron Master™ Diopters A measurement of the power of a lens

5. Purpose To investigate whether extended use of CRT lenses has a significant impact on the health of the cornea through the use of fluorophotometry

6. Extended use of CRT lenses will not significantly affect corneal permeability Hypothesis

7. Methods 1. Obtained Approval from Review Board 2. Put up Flyers around the Mount Sinai Hospital and the surrounding neighborhood 3. Screening Sessions for qualification( 18 patients with refractive errors between -0.5 to - 4.0 diopter 4. Full length eye exam to see health before the use of CRT lenses 5. Day of Fitting: baseline readings taken by the Fluorotron Master

8. Methods Continued 6. Washed eyes with standard Saline after twenty minutes 7. Two post wash scans were taken of each eye 8. Peak corneal florescence values were measured by fluorophotmetry (indicated epithelial permeability 9. Subsequent scans of the cornea taken one day, one week, one month, and three months after the initial fittings 10. Compared pre-fitting values to changes

9. Results After nightly use of CRT – Post CRT incorrected visual acuity was 20/20 or better in 15 of 18 patients by day 7 Conclusion CRT is effective in correcting myopic refractive errors

10. Future Studies This study is ongoing and longer follow up data will be analyzed

11. Acknowledgements Dr. Penny Asbell Dr. Elvin Yildiz Mount Sinai School of Medicine Dr. Sat Bhattacharya Harlem Children Society HCS Staff

12. References 1. Swarbrick, HA. Corneal Response to Orthokeratology. Optom Vis Sci. 1998;75:773.Optom Vis Sci. 1998;75:773. 2. Ladage, P. What does Overnight Lens Wear Do to the Corneal Epithelium?: Is Corneal Refractive Therapy Different?. Eye and Contact Lens 2004;30:194-197. 3. Paragon Vision Sciences, Paragon CRT FDA Professional Fitting and Information Booklet. June 2002, page 5. 4. Walline et al The Current state of Corneal Reshaping Eye & Contact Lens 2005 (31)5: 209-214, 2005 5. Watt K, Swarbrick HA. Microbial keratitisin overnight orthokeratology: review of the first 50 cases. Eye Contact Lens 2005; 31: 201–208. 6. Eef van der Worp et al Orthokeratology: An Update Optometry in Practice Vol 7 (2006) 47–60 7. Walline et al The Current state of Corneal Reshaping Eye & Contact Lens 2005 (31)5: 209-214, 2005 8. Eef van der Worp et al Orthokeratology: An UpdateOptometry in Practice Vol 7 (2006) 47–60 9. Lang, Jacob O.D.; Rah, Marjorie J. O.D., Ph.D., F.A.A.O. Adverse Corneal Events Associated With Corneal Reshaping: A Case Series Eye Contact Lens. 2004 Oct;30(4):231-3; discussion 242-3