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1 A follow up study of mild cognitive impairment in Beijing ----finding from 10/66 study Zhaorui Liu, Chuanjun Zhuo, Yueqin Huang, Shuran Li, Institute of Mental Health, Peking University Martin Prince Institute of Psychiatry, King’s College London
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2 Background A new dementia case every 7 seconds Cost of dementia: 1% of Global GDP Early intervention: crucial MCI - early dementia?
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3 Background Incidence study on MCI: (65+) Ravaglia : 4-year cumulative incidence 22.6% Larrieu : 99/1000 person year Solfrizzi : incidence: 2.76% Zhu : 5-year cumulative incidence:8.0% Transition MCI-dementia : 10% ~ 15% every year Normal-dementia: 1.6% ~ 3% every year
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4 Objectives To describe the incidence of mild cognitive impairment (MCI) To analyze the transition from MCI to dementia To explore risk factors of MCI incidence and the transition
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5 Design Part of 10/66 study in China Two settings: Rural-Daxing, Urban- Xicheng Baseline: 2004 Follow-up study: 2009 2012 older persons
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6 Subjects Incidence part: 1859 older persons with normal cognitive function elderly at the baseline Transition part: 166 MCI patients at the baseline
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7 Measurements Cognitive Test: CSID Geriatric Mental State-B3 version Informant Interview Questionnaire Background Socio- demographic and Risk factor Questionnaire Self-report chronic diseases, physical examination
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8 Diagnose MCI were diagnosed according to the general MCI criteria developed by Stockholm international conference. Cognitive impairment, not dementia Self-report or informant-report cognitive impairment independent activities of daily life, complex task slightly affected
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9 Flow chart Incidence part Baseline 2162 Dementia 137 MCI 166 Normal cognitive function 1859 Missing 190 Died 428 New MCI case 193
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10 Results Incidence of MCI 5-year cumulative incidence 10.38% Average annual incidence rate was 2.17% (95%CI: 1.76~2.30%) Age groups Male Female
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11 Results Incidence of MCI 5-year cumulative incidence 10.38% Average annual incidence rate was 2.17% (95%CI: 1.76~2.30%) Urban Rural No-education Primary Secondary Tertiary
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12 Results Cox regression Risk factors of MCI older age living in a rural area lower education history of stroke history of diabetes larger Waist Hip Ratio Protective factors of MCI having spouse physical exercise
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13 Flow chart Transition part Baseline MCI 166 Missing 7 found 159 Died 54 Normal 10 Dementia 74
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14 Results MCI to dementia 5-year cumulative transition rate 43.97%, Average annual transition rate was 10.94% ( 95%CI: 7.30-12.18% ) Protective factors of the transition having spouse physical exercise Risk factors of the transition older age living in a rural area lower education history of stroke hypertension heart disease
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15 Contribution Similar risk factors are found for the MCI occurrence and conversion as well. This study provides a foundation for future prevention and intervention of MCI, which are of significant social and clinical value.
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16 Corresponding to Prof. Yueqin HUANG huangyq@bjmu.edu.cn
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