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1 A follow up study of mild cognitive impairment in Beijing ----finding from 10/66 study Zhaorui Liu, Chuanjun Zhuo, Yueqin Huang, Shuran Li, Institute.

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Presentation on theme: "1 A follow up study of mild cognitive impairment in Beijing ----finding from 10/66 study Zhaorui Liu, Chuanjun Zhuo, Yueqin Huang, Shuran Li, Institute."— Presentation transcript:

1 1 A follow up study of mild cognitive impairment in Beijing ----finding from 10/66 study Zhaorui Liu, Chuanjun Zhuo, Yueqin Huang, Shuran Li, Institute of Mental Health, Peking University Martin Prince Institute of Psychiatry, King’s College London

2 2 Background  A new dementia case every 7 seconds  Cost of dementia: 1% of Global GDP  Early intervention: crucial  MCI - early dementia?

3 3 Background  Incidence study on MCI: (65+) Ravaglia : 4-year cumulative incidence 22.6% Larrieu : 99/1000 person year Solfrizzi : incidence: 2.76% Zhu : 5-year cumulative incidence:8.0%  Transition MCI-dementia : 10% ~ 15% every year Normal-dementia: 1.6% ~ 3% every year

4 4 Objectives  To describe the incidence of mild cognitive impairment (MCI)  To analyze the transition from MCI to dementia  To explore risk factors of MCI incidence and the transition

5 5 Design  Part of 10/66 study in China  Two settings: Rural-Daxing, Urban- Xicheng  Baseline: 2004  Follow-up study: 2009  2012 older persons

6 6 Subjects  Incidence part: 1859 older persons with normal cognitive function elderly at the baseline  Transition part: 166 MCI patients at the baseline

7 7 Measurements  Cognitive Test: CSID  Geriatric Mental State-B3 version  Informant Interview Questionnaire  Background Socio- demographic and Risk factor Questionnaire  Self-report chronic diseases, physical examination

8 8 Diagnose  MCI were diagnosed according to the general MCI criteria developed by Stockholm international conference.  Cognitive impairment, not dementia  Self-report or informant-report cognitive impairment  independent activities of daily life, complex task slightly affected

9 9 Flow chart  Incidence part Baseline 2162 Dementia 137 MCI 166 Normal cognitive function 1859 Missing 190 Died 428 New MCI case 193

10 10 Results  Incidence of MCI 5-year cumulative incidence 10.38% Average annual incidence rate was 2.17% (95%CI: 1.76~2.30%) Age groups Male Female

11 11 Results  Incidence of MCI 5-year cumulative incidence 10.38% Average annual incidence rate was 2.17% (95%CI: 1.76~2.30%) Urban Rural No-education Primary Secondary Tertiary

12 12 Results  Cox regression  Risk factors of MCI  older age  living in a rural area  lower education  history of stroke  history of diabetes  larger Waist Hip Ratio  Protective factors of MCI  having spouse  physical exercise

13 13 Flow chart  Transition part Baseline MCI 166 Missing 7 found 159 Died 54 Normal 10 Dementia 74

14 14 Results  MCI to dementia 5-year cumulative transition rate 43.97%, Average annual transition rate was 10.94% ( 95%CI: 7.30-12.18% )  Protective factors of the transition  having spouse  physical exercise  Risk factors of the transition  older age  living in a rural area  lower education  history of stroke  hypertension  heart disease

15 15 Contribution  Similar risk factors are found for the MCI occurrence and conversion as well.  This study provides a foundation for future prevention and intervention of MCI, which are of significant social and clinical value.

16 16 Corresponding to Prof. Yueqin HUANG huangyq@bjmu.edu.cn


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