1. NCDD Meeting 11-19-07 Outline Table of Contents Chapter Examples –GI infections –Colorectal cancer Cost of Digestive Diseases National Endoscopy Data

2. Contents Chapter 1: Introduction Chapter 2: Intestinal Infections Chapter 3: Viral Hepatitis Chapter 4: Esophageal Cancer Chapter 5: Gastric Cancer Chapter 6: Cancer Of The Small Intestine Chapter 7: Colorectal Cancer Chapter 8: Liver Cancer Chapter 9: Bile Duct Cancer Chapter 10: Gallbladder Cancer Chapter 11: Pancreatic Cancer Chapter 12: Any Digestive Cancers

3. Contents (continued) Chapter 13: Hemorrhoids Chapter 14: Gastroesophageal Reflux Disease Chapter 15: Peptic Ulcer Disease Chapter 16: Functional Disorders Chapter 17: Appendicitis Chapter 18: Abdominal Wall Hernia Chapter 19: Inflammatory Bowel Disease Chapter 20: Diverticular Disease Of The Intestine Chapter 21: Acute And Chronic Liver Disease Chapter 22: Gallstones Chapter 23: Acute And Chronic Pancreatitis Chapter 24: Celiac Disease

4. Contents (continued) Chapter 25: Any Digestive Diseases Chapter 26: Endoscopy (National Endoscopy Database) Chapter 27: Cost Of Digestive Diseases Chapter 28: Conclusion Appendix 1: Summary Of Surveys Used In The Burden Report Appendix 2: ICD-9-CM, ICD-9, AND ICD-10 DIGESTIVE DISEASE CODES

5. Ambulatory Care Visits and Hospital Discharges with First-Listed and Any-Listed Diagnoses of Intestinal Infections by Age, Race, and Sex in the United States, 2004

6. Deaths and Years of Potential Life Lost (to age 75) from Intestinal Infections by Age, Race, and Sex in the United States, 2004

7. Intestinal Infections ICD-9 001-009

8. Age-Adjusted Rates of Ambulatory Care Visits and Hospital Discharges With All-Listed Diagnoses of Intestinal Infections in the United States, 1979–2004 SOURCE: National Ambulatory Medical Care Survey, National Hospital Ambulatory Medical Care Survey, and National Hospital Discharge Survey

9. Age-Adjusted Rates of Deaths From Intestinal Infections in the United States, 1979–2004 SOURCE: Vital Statistics of the United States

10. Most Costly Prescriptions for Intestinal Infections DrugRx #Rx %Retail cost ($)Cost % Levofloxacin 1,265,36816.7%109,871,828 31.1% Ciprofloxacin 670,0808.8%88,932,185 25.2% Prochlorperazine 1,947,88825.7%40,064,734 11.3% Vancomycin 17,8020.2%27,525,530 7.8% Moxifloxacin 322,7224.3%27,432,212 7.7% Promethazine 640,1178.5%23,243,001 6.6% Gatifloxacin 201,4302.7%15,340,499 4.3% Metronidazole 662,7008.7%7,443,865 2.1% Diphenoxylate 285,9343.8%4,697,608 1.4% Loperamide 154,8372.0%1,828,348 0.5% Total top 10 6,168,87881.4%$346,379,810 98.0% Source: Verispan

11. Number of Cases and Incidence Rate of Colorectal Cancer by Age, Race/Ethnicity, and Sex, 2004 SOURCE: Surveillance, Epidemiology, and End Results (SEER) Program

12. Age-Adjusted Incidence Rate and 5-Year Survival Rate for Colorectal Cancer, 1979–2004 SOURCE: National Ambulatory Medical Care Survey, National Hospital Ambulatory Medical Care Survey, and National Hospital Discharge Survey

13. Direct, Indirect, and Total Costs of Digestive Diseases in the United States, 2004

14. Direct Costs of Digestive Diseases in the United States, 2004 (continued)

15. Indirect Costs of Digestive Diseases in the United States, 2004 (continued)

16. Characteristics of Endoscopy Sites, 2001–2005, in the National Endoscopy Database

17. Number of Endoscopic Procedures at “Stable” Sites (N=36) by Year, 2001–2005

18. Number of Colonoscopies at “Stable” Sites (N=36) by Age (Years) and Year

19. Colonoscopy: Top Five Indications, 2001–2005 (N=542,650) Indications are not mutually exclusive.

20. Colonoscopy: Top Five Findings in the Total Population and Persons at Routine Risk, 2001–2005 Findings are not mutually exclusive

21. Colonoscopy Findings in Persons at Routine Risk by Age, 2001–2005 Diverticulosis Normal