1. The Integumentary System Chapter 5

2. The Integumentary System Composed of the skin, sweat and oil glands, hair, and nails. Accounts for 7% of the body’s weight. Major role is protection from pathogens and dehydration. Varies in thickness from 1.5 to 4.0 mm. Composed of 3 distinct layers. Epidermis, Dermis, and hypodermis or superficial fascia

4. Epidermis Outermost layer. Composed mostly of keratinized stratified squamous epithelium. Contains 4 distinct cell types and 4 to 5 distinct layers.

5. Cell Types of the Epidermis Keratinocytes—produce keratin, a fibrous protein that give the epidermis its protective properties. These cells are tightly connected by desmosomes. Arise from the stratum basale. Undergo continuous mitosis. Are pushed upward and continuously become more keratinized.Those on the surface of the skin are dead. Millions rub off per day. Friction may lead to a thickening of the cells known as a callus.

6. Cell Types of the Epidermis Melanocytes—synthesize melanin. Located at the deepest layer of the epidermis. The melanin is transferred to the keratocytes. Protects against UV damage.

7. Cell Types of the Epidermis Langerhans’ cells—arise from the bone marrow. Act as macrophages that activate the immune system. Merkel cells—present at the junction of the epidermis and dermis. Associated with sensory receptors.

9. The Dermis Made mostly of connective tissue. The hide of the human body. Richly innervated and vascularized. Contains the hair follicles, sweat glands, oil glands, lymphatic vessels, and many sensory receptors.

11. The Dermis Skin color—determined by melanin, carotene, and hemoglobin. Why do different people have different skin colors? Freckles & moles Role of melanin Role and source of carotenes & hemoglobins.

12. Skin Appendages Sweat Glands—more than 2.5 million per person. Eccrine sweat glands—coil in the dermis, a duct leads to a pore at the skin’s superficial surface. Sweat contents How does sweat work? Apocrine sweat glands—in the axillary and anogenital areas. Empty into hair follicles. Contains fatty substances and proteins. May cause body odor. Begin to function at puberty. May contain pheromones.

13. Skin Appendages Ceruminous glands—secrete earwax. Mammary glands—secrete milk. Sebaceous Glands—oil glands. Found everywhere except the palms and soles. Secrete sebum.Usually secreted into hair follicles. Bactericidal + other functions.

14. Skin Appendages Whiteheads Blackheads Acne—staphylococcus Hair—covers the entire body except for the palms, soles, lips, nipples, and parts of the genitalia. Functions of hair. Mostly dead keratinized cells.

15. Hair Parts of the hair –Shaft Medulla Cortex Cuticle –Split ends –Root –Hair color –Hair follicle Hair bulb Root hair plexus Arrector pili—How and why is this important? Hair papilla

17. Hair Vellus Hairs Terminal Hairs—androgen sensitive Electrolysis Hirsutism Alopecia Male-pattern baldness Sex-influenced trait

18. Nails Modification of the epidermis Composed of keratin. Composed of a free edge, body, and a root. Nail bed—epidermis under the nail. Nail matrix—growth occurs here. Lunula cuticle

21. Functions of the Integument Chemical barriers—acid mantle, human defensin Biological Barriers—Langerhan’s cells and macrophages. Physical barrier –Some substances can cross the skin. Lipid soluble substances. Oleoresins—poison ivy. Organic solvents. Salts of heavy metals

22. Functions of the Integument Temperature Regulation –Sweat glands –Vasodilation and vasoconstriction Cutaneous Sensation –Meissner’s corpuscles –Pacinian corpuscles –Root hair plexuses –Pain and heat/cold receptors Metabolic Functions –Vitamin D synthesis Blood Reservoir –Shunts more blood into the circulation when needed. Excretion

24. Skin disorders Causes Basal cell carcinoma—30% of caucasians get this type of skin cancer. Does not metastasize. Squamous Cell carcinoma—arises from the keratinocytes in the stratum spinosum. May metastasize. Melanoma—arises in the melanocytes. Rapidly metastasizes. ABCD rule– Asymmetry, Border irregularity, Color, Diameter

25. Burns Denaturation of cell proteins. Dehydration, protein loss, and infection. First degree burns—only the epidermis. Second degree burns—epidermis and upper dermis. May include blisters. Third degree burns—full thickness. Not painful. Skin grafting is almost always necessary. Grafting techniques Autograft Dangers of facial burns and burns near joints.

26. Aging Effects Lanugo Coat Vernix Caseosa Thinning of the skin Slowing of epidermal cell replacment.