1. Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

2. NORMAL ANATOMY

4. SAGITAL SECTION OF THE PROSTATE GLAND Seminal Vesicle Central Zone Bladder Peri-urethral zone Anterior Zone Fibro-muscular Peripheral Zone Transition Zone Urethra

5. 3D VIEW OF THE PROSTATE

7. CROSS SECTION OF THE PROSTATE FIBROMUSCULAR STROMA anterior PERI-URETHRAL STROMA EJACULATORY DUCTS

8. TRANZITIONAL ZONE Seminal Vesicle Urethra

9. CENTRAL ZONE

10. Peripheral Zone

11. Fibro-muscular Stroma anterior

12. HISTOLOGY

13. Bad Histology

14. Peripheral Zone

15. Central Zone

20. 40X Seminal Vesicles

21. 20X Seminal Vesicles

22. 20X

23. Paraganglion

24. Neurons40X

25. Benign Lesions

26. Inflammation

27. Acute Inflammation

31. Granuloma

32. 20X Corpora Amylacea

33. 20X Calcified

34. 200XCristalloid

35. 200X Stromal Nodules

36. H Y P E R P L A S I A

37. PRIMARY NODULAR HYPERPLASIA

38. Cell Type Mesenchymal Fibroblast Smooth Muscle Basal Cells Secretory Cells Special PatternsUsual Patterns Predominantly stromal Predominantly glandular Mixed Small Cell Hyperplasia Leiomatous Hyperplasia Basal Cell Hyperplasia Crybiform Hyperplasia BENIGN NODULAR HYPERPLASIA

41. BPH & Inflammation

43. BASAL CELL HYPERPLASIA

44. 200X

45. BASAL CELL HYPERPLASIA

46. BASAL CELL HYPERPLASIA - HMWCK

47. ATROPHY

48. 20X SIMPLE ATROPHY

49. 200X ATROPHY

50. 40X ATROPHY

51. 10X CYSTIC ATROPHY

52. PIN Prostatic Intraepithelial Neoplasia

53. Secretory cells Lumen Basal Cells Basal Membrane Normal Dysplasia Carcinoma MildModerate Severe In situ Microinvasive Low GradeHigh Grade Prostatic Intra-epithelial Neoplasia Prostatic Intraepithelial Neoplasia

54. Prostatic Intra-epithelial Neoplasia

57. It continues in Part 2