1. Lecture 16 Get Lecture Problem 6 The Synthetics This Week in Lab:
Ch 9 PreLab Due
Quiz 5
Ch 6 Final Report Due
Next Week:
Spring Break!!!

2. The Condensation Reactions
Experiment 14: Synthesis of 3-Carbethoxycoumarin
Go over mechanisms for transesterifcation & aldol condensation in class

3. The Condensation Reactions
Experiment 16: Synthesis of Creatine
Go over mechanism in class.

4. Esterification Synthesis of esters
A Typical Esterification (generic example):
reaction of a carboxylic acid (elec) with an alcohol (nuc)
acid catalyzed
reversible
known as a Fisher Esterification

5. Esterification Experiment 80: Synthesis of Aspirin
Reaction of an alcohol (nuc) with an anhydride (elec)
Similar mechanism to Fisher esterification
Analyses: IR & NMR
Aspirin:
Anti-inflammatory
analgesic (pain killer)
Antipyretic (fever reducer)

6. More Esterifications Experiment 86: Synthesis of Benzocaine
Fisher esterification reaction
Analyses: IR, NMR & MS
Benzocaine:
Topical local anesthetic for itching and pain caused by sunburn, insect
bites, poison ivy, poison oak, minor cuts
Deadens the nerve endings in the skin

7. Fragrant Esters
Analyses: IR, NMR,
GC, GC-MS, MS