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毒物分析 授課教師:賴滄海教授 03-28-2008 LC-MS of drugs of abuse and related compounds.

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Presentation on theme: "毒物分析 授課教師:賴滄海教授 03-28-2008 LC-MS of drugs of abuse and related compounds."— Presentation transcript:

1 毒物分析 授課教師:賴滄海教授 03-28-2008 LC-MS of drugs of abuse and related compounds

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17 Rapid Commun. Mass Spectrom.2005;19:1332-1338 Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library searching

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22 Chiral analysis of methadone and its major metabolites (EDDP and EMDP) by liquid chromatography-mass spectrometry journal of Chromatography B, 814 (2005) 315-323

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30 Doping substances  Diuretics Narcotics  β 2 -Blockers Cannabis  Steroids HCG Erythropoietin  Stimulants HGH Insulin, HBOC

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32  Figure 9.1 Diuretics with thiazide structure are converted by hydrolysis or sulphoxidation during sample transportation, storage or preparation, which may cause analytical problems in GC-MS. Respective artefacts need to be factored into LC-MS screening

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