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The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern.

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Presentation on theme: "The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern."— Presentation transcript:

1 The four units of the Ca 2+ signalling network Nature Rev. Mol. Cell Biol. 1, 11-21 (2000) Speed Amplitude Spatio-temporal pattern

2 Spatial aspects of Ca 2+ signalling Nature 395, 645 - 648 (1998)

3 Basic Mechanisms of Ca 2+ Signalling

4 Elements of the Ca 2+ signalling toolkit Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

5 quarks/sparks blips/puffs

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7 [IP 3 ] and lumenal Ca 2+ modulate the shape of the bell-shaped curve Current Biology 1999, 9:R876-R878

8 The steps leading to activation or inactivation of IP 3 receptors Current Biology 1999, 9:R876-R878

9 Ca 2+ signalling by conformational coupling using macromolecular complexes Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)  1s

10 Application of the Ca 2+ signalling toolkit to regulate different cellular processes Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

11 The spatial organization of Ca 2+ release from internal stores Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

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13 Schematic representation of the mitochondrial Ca 2+ transport pathways in energized mitochondria

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15 3-D imaging of mitochondrial and ER structure in living HeLa cells M ER

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19 Structural Organization of the Endoplasmic Reticulum in Neurons Neuron, 21, 13–26, (1998)

20 Binary Membrane System of Neural Calcium Signaling Neuron, 21, 13–26, (1998)

21 Proposed Role of Ca 2+ Signaling in Neuronal Gene Transcription Neuron, 21, 13–26, (1998)

22 Compartmentalization of Ca 2+ signals in neurons Nature 395, 645 - 648 (1998)

23 A Ca 2+ nexus — crosstalk between signalling pathways L-VDCC IP 3 R Nature Rev. Mol. Cell Biol. 1, 11-21 (2000)

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25 Schematic structures and sequences of cameleons Nature (1997) 388, 882-887

26 Nature Reviews Neuroscience (2002) 3, 175-190

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29 Immobilization and superfusion of CaM kinase II Science 279, 227-230 (1998)

30 Properties of immobilized CaM kinase II Science 279, 227-230 (1998)

31 Stimulation of CaM kinase II by pulse flow Science 279, 227-230 (1998)

32 Modulation of the frequency response of CaM kinase II Science 279, 227-230 (1998)

33 Calcium rollercoaster Science 279, 191-192 (1998)


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