1. Amlodipine -Calcium Channel Blocker-
목희연

2. Amlodipine
화학명
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester 분류
고혈압 치료제 (dihydropyridine 계열) 약리
Calcium Channel Blocker
적응증
고혈압
상품명
Norvasc
개발회사
Pfizer

3. Calcium Channel Blocking Drugs
∙Three Classes of CCBDs
Chemical Type
Chemical Names
Brand Names
Phenylalkylamines
Verapamil
Calan,
Isoptin
Benzothiazepines
Diltiazem
Cardizem
1,4-Dihydropyridines
Nifedipine
Nicardipine
Isradipine
Felodipine
Amlodipine
Adalat,
Procardia
Cardene
DynaCirc
Plendil
Norvasac
Verapamil

4. Calcium Channel Blocking Drugs
∙Three Classes of CCBDs
Chemical Type
Chemical Names
Brand Names
Phenylalkylamines
Verapamil
Calan,
Isoptin
Benzothiazepines
Diltiazem
Cardizem
1,4-Dihydropyridines
Nifedipine
Nicardipine
Isradipine
Felodipine
Amlodipine
Adalat,
Procardia
Cardene
DynaCirc
Plendil
Norvasac
Diltiazem

5. Calcium Channel Blocking Drugs
∙Three Classes of CCBDs
Chemical Type
Chemical Names
Brand Names
Phenylalkylamines
Verapamil
Calan,
Isoptin
Benzothiazepines
Diltiazem
Cardizem
1,4-Dihydropyridines
Nifedipine
Nicardipine
Isradipine
Felodipine
Amlodipine
Adalat,
Procardia
Cardene
DynaCirc
Plendil
Norvasac
Amlodipine

6. Calcium channel

7. Voltage-gated Calcium channel
Type
Most often found in
L-type calcium channel ("Long-Lasting" AKA "DHP Receptor")
골격근, 평활근, 심장근육
P-type calcium channel ("Purkinje") /Q-type calcium channel
푸르키니에 섬유
N-type calcium channel ("Neural"/"Non-L")
뇌 신경
R-type calcium channel ("Residual")
소뇌 과립세포
T-type calcium channel ("Transient")
신경세포, 심장근육

8. Calcium binding mechanism

9. Calcium channel Blocking
혈관확장, 동방결절 전기 신호 억제

10. Effects of CCBDs 혈관확장 심장수축저해 동방결절억제 방실결절억제
1,4-Dihydropyridines
Benzothiazepines
Phenylalkylamines
혈관 선택성 Ca2+ 길항작용 : 1,4-Dihydropyridines
심장 선택성 Ca2+ 길항작용 : Phenylalkylamines, Benzothiazepines

11. Thank You