1. Evaluation of Interface Reflectivity and Corneal Aberrations following DSAEK Hamid Khakshoor, MD Professor of Ophthalmology Mashhad University of Medical Sciences,Iran Maliheh Nikandish MD, Amirhosein Vejdani MD, Maryam Salehi MD, Haleh Ghooshkhanehei MD WCCVII 2015

2. Authors have no financial interest in the subject matter of this poster.

3. Purpose We assessed visual outcome after descemet membrane stripping automated endothelial keratoplasty (DSAEK) and relate to interface and corneal Higher-Order Aberrations (HOAs)

4. Materials & Methods We enrolled 16 eyes of 16 patients (8 males and 8 females) in this interventional case series and followed after DSAEK operation for about 2-20 months. Interface reflectivity and HOAs were examined by OCULUS Pentacam as well as other ophthalmic evaluations in follow up visits.

5. Materials & Methods Data analysis was performed using available software SPSS for Windows (version 11.5, SPSS Inc, Chicago, Illinois). Correlation was studied by means of Pearson Correlation Coefficient. Difference was considered statistically significant if the P value was <0.05. A correlation of 0.4-0.7 regarded as medium, 0.7- 0.9 good, 0.9 high and a value less than 0.4 indicated low.

6. ResultsResults The mean age was 62.69 (ranged from 13 to 78 years). There was statistically significant correlation between interface reflectivity and Best Corrected Visual Acuity (BCVA) (r=0.56, p=0.021). Pachymetry (central corneal thickness) and BCVA had a moderate correlation(r=0.6, p=0.013).There was no statistically significant correlation between pachymetry and follow up time(r= - 0.36, p=0.16). Negative correlation between follow up and interface reflectivity was also not statistically significant(r= - 0.24, p=0.35). Coma had a significant correlation with BCVA in cornea and cornea front maps (r=0.74, p=0.009 and r=0.71, p=0.013 respectively). At the final visit, best spectacle-corrected visual acuity (BSCVA) had increased to 0.63 (range 0.1-1.6 log MAR).

7. Negative correlation between follow up and interface reflectivity (p=0.35)

8. Correlation between pachymetry and interface reflectivity (p= 0.001)

9. Relationship between interface reflectivity and BCVA (p=0.021)

10. Scheimpflug images by Pentacam system demonstrate corneal (A), anterior corneal (B) and posterior corneal HOAs in an eye underwent DSAEK (C).

11. Conclusions Significant correlation between interface reflectivity and BSCVA was found. Anterior corneal HOAs are significantly higher than posterior HOAs. There was no significant correlation between any of the Zernike terms from total and anterior corneal HOAs of the central 6-mm zones and BCVA. Exception: coma of total cornea and anterior cornea HOAs maps