1. Unsteady hemodynamic simulation of cerebral aneurysms А.А.Cherevko, А.P.Chupakhin, А.А.Yanchenko ( IGiL SB RAS, NSU)

2. Place the appearance of aneurysms: bifurcation of vessels, space anatomical changes structure of vessels, next to the arteriovenous malformation. The reasons of occurrence: structural changes in the arteries, hemodynamic factor, mechanical damage of the vessel wall. Found in 0.3-5% of the adult population, a rare occurrence in children. Aneurysmal wall material differs from the material of a healthy vessel wall. Aneurysm - a diverticulum the arterial wall due to its stretching

3. Endovascular treatment of aneurysms Аневризма treatment: embolization stenting riskiness : rupture recanalization aneurysm catheter

4. Aneurysms hemodynamic modeling Preoperative simulation should be carried out quickly enough - 1-2 days The most simple and effective model, giving sufficient accuracy Geometry of aneurysm - tomography data ( NNIIPK ) Flow parameters - intravascular pressure and velocity sensor ( NNIIPK ) CFD calculations – ANSYS (IGiL, NSU computer cluster) What hemodynamic parameters determine the effectiveness of the operation? What is the safe range of variation of these parameters? Stages of work: Reconstruction of the geometry from the CT scan Numerical simulation of hemodynamics with fixed walls of the vessel Simulation of the stress-strain state of the wall using the pressure distribution obtained in the previous stage of the calculation

5. Vessel geometry beforeafter control a year later Progressive rectification of bifurcation

6. Mathematical Statement of the Problem Blood flow described by the Navier-Stokes equations for three-dimensional motion of an incompressible, viscous Newtonian fluid where v - velocity, p - pressure, ν - the kinematic viscosity, Ω - the internal volume of the computational domain, including the configuration of the vessels in the form of the tee and an aneurysm located at the bifurcation. γ = ∂ Ω - boundary wall of the vessel. Boundary conditions: where v real and p real - speed and pressure, taken from the sensor during operation. Г in - cross section of the parent vessel tee; Г 1out, Г 2out - cross sections of child vessels

7. The computational domain (Before surgery)

8. Clinical velocity and pressure data

9. Hydrodynamics

10. computational grid Used computational grid of tetrahedra. When mesh refinement is 5 times - deviation of pressure is less than 1%, slightly larger deviations (up to 5%) observed in the values ​​ of the velocity modulus. Further refinement grid has almost no influence on the result.

11. streamlines (up to stenting) High speeds, vorticity within the aneurysm.

12. Streamlines (after stenting) Reducing the area of ​​ maximum speed. The appearance of "almost circular" vortex.

13. Streamlines (control a year later) Weak vorticity, velocity decreased.

14. WSS (up to stenting) Clearly visible zones of large WSS on bends (not on the cupola!).

15. WSS (after stenting) Zones of large WSS decreased.

16. WSS (control a year later) Zone of high stress is very small, almost all within the normal range (1.5-2 Pa).

17. Energy flux (up to stenting) Loss of energy flux is ~ 9%, which is quite a large value at longer tee is approximately equal to 2 cm

18. Energy flux (after stenting) After surgery, vascular geometry is restored almost to the health and loss constitute ~ 4%.

19. Energy flux (control a year later) Energy loss is ~ 1%.

20. mechanics

21. wall parameters vesselaneurysm Young's modulus 1 МPа1.2 МPа Poisson's ratio 0.49 wall thickness 4,e-4 m1,e-4 m Unsteady calculation. Aneurysm's zone has a different properties.

22. Total deformation and von-Mises stress (up to stenting) Maxima concentrated on the aneurysm's cupola. Compared with the stationary calculations: maximum deformations slightly increased. Stress are increased (4.335e5 against 3.0894e5). Localization of maximums is not changed.

23. Total deformation and von-Mises stress (after stenting) Maximum values ​​ decreased slightly. Compared with the stationary calculations: Localization of maximums is not changed.

24. Total deformation and von-Mises stress ( control a year later) The maximum strain decreased by 2 times, the maximum stress at 1/3.

25. Comparison of simulation results. (Maxima of displacement and von- Mises stress) beforeaftera year later Steady9.3551e-1 mm 3.0894e5 Pа 8.2307e-1 mm 3.1445e5 Pа 4.6604e-1 mm 2.2557e5 Pа Transient1.3116 mm 4.3346e5 Pa 1.0937 mm 4.1624e5 Pa 6.1321e-1 mm 2.9726e5 Pa 1 mm Hg = 133.322 Pа

26. conclusions Maxima of stresses and displacements in the steady and unsteady calculations based differ in magnitude, but do not differ by location. To identify "dangerous places" stationary calculation with allocation of area of the aneurysm can be used. To find the magnitudes of stresses and displacements ​​need to use unsteady calculations with allocation of area of the aneurysm. Unsteady calculation without separation zone of the aneurysm is not sufficiently accurate

27. Time costs: Steady calculation: a few minutes Transient calculation: 3 hours for 1 simulation second

28. Thank you for your attention!