1. NEURAL TRANSMISSION

2. NEUROTRANSMITTERS Dopamine Dopamine Serotonin Serotonin Adrenaline (Epinephrine) Noradrenaline (Norepinephrine) Acetylcholine

5. dopamine transporters

6. Di Chiara et al., Neuroscience, 1999.,Fiorino and Phillips, J. Neuroscience, 1997. Natural Rewards Elevate Dopamine Levels 0 50 100 150 200 060120180 Time (min) % of Basal DA Output NAc shell Empty Food Sex Box Feeding 100 150 200 DA Concentration (% Baseline) Sample Number 12345678 Female Present

8. Dopamine and Parkinson’s Disease

9. Serotonin Present in high amounts when awake. Keeps us alert and attentive Affects mood. Depressive & anxious individuals also show sleep disorders Chemical precursor of melatonin – which regulates the biological clock and is present in high concentration at night when asleep Affects perception, cognition and appetite

10. Serotonin and MDMA (Ecstasy)

11. Links to Videos and Pictures Videos: Neural Transmission: http://www.youtube.com/watch?v=c5cab4hgmoE Dopamine and Parkinson’s Disease: http://www.youtube.com/watch?v=jyBakRkzswU&list=PL2FC544 CF1B5A32C5 Serotonin and MDMA (Ecstasy): http://www.youtube.com/watch?v=CFZ8E1-HA-E Pictures: http://www.drugabuse.gov/publications/addiction-science