1. doi:10.1371/journal.pbio.0060175 Scivee Pubcast

2. 2 Community intelligence Traditional media revolves around the Short Head – a few number of publishers putting out lots of content “Web 2.0” media revolves around community generated content – a huge population of individuals each generating a (relatively) small amount of content Users Content The Short Head Newspapers TV/Hollywood Consumer Reports Olympics Encyclopedia Britannica The Long Tail Blogs YouTube Amazon reviews American Idol Wikipedia “Community intelligence”

3. 3 “ Wikipedia Wiki: “… a website that allows the visitors themselves to easily add, remove, and otherwise edit and change available content, typically without the need for registration.” Wikipedia: “the free encyclopedia that anyone can edit.” An expert-led investigation carried out by Nature … revealed numerous errors in both encyclopaedias, but among 42 entries tested, the difference in accuracy was not particularly great: the average science entry in Wikipedia contained around four inaccuracies; Britannica, about three.

4. 4 Advantages of a Gene Wiki 1) Existing gene portals are great for structured content, but a wiki is suited for summarizing unstructured content Entrez GeneWikipedia Unstructured content allows for free-text, images, diagrams, photos, etc.

5. 5 Advantages of a Gene Wiki 2) Wiki articles enable two-way communication of information, encouraging contributions and edits from the community. October 22, 2002, 1 edit/editor, 139 words November 2004, 21 editors, 35 edits, 745 words October 2, 2006, 115 editors, 226 edits, 2274 words “In 2006, Americans Andrew Fire and Craig C. Mello won the Nobel Prize in Physiology or Medicine for their work on RNA interference.” July 2008, 250 editors, 751 edits, 9429 words, 9 figures Wikipedia is rarely the last place you look, but is often a good first place for an overview.

6. 6 Gene “stubs” Active MCB community at WP had already developed ~650 gene articles Can we accelerate this process through stub creation? In total, created 7500 new articles and edited 650 previously existing articles.

7. 7 Gene wiki usage (650) (7500) 50% of all edits to gene pages are to newly-created pages… Gene Wiki pages are highly ranked at Google, ensuring critical mass of users and editors… Current have ~9000 gene pages or stubs at Wikipedia A Weeks before/after bot edit Avg. edits / page / week Google rank

8. 8 Gene Wiki network is scale-free Scale-free networks have roughly constant diameter regardless of network size Mirrors scale-free property of other biological networks # Links # Pages

9. 9 Positive feedback loops Gene wiki page utility Number of readers Number of editors 100 1 200 2

10. 10 25k gene-specific review articles? Hyperlinks to related concepts

11. 11 Caveats and qualifications The Gene Wiki is complementary to, and not in competition with, existing gene portals Users must be aware of the advantages and disadvantages of the Gene Wiki’s open editing model Other community intelligence models are valuable and are being explored

12. 12 Links Project home: http://en.wikipedia.org/wiki/User:ProteinBoxBot List of all Gene Wiki pages Link to the discussion page Editing 101 for Gene Wiki users Entrez Gene lookup