1. Efficacy of Internet-based Interventions for Children, Youth, and Young Adults with Anxiety and/or Depression: A Systematic Review and Meta-Analysis Xibiao Ye CHI Evaluation Platform, Winnipeg Regional Health Authority, Manitoba Department of Community Health Sciences, Faculty of Medicine, University of Manitoba

2. Why this knowledge synthesis? Low access to mental health treatment services CIHR Access to Mental Health Services for Children and Youth knowledge synthesis priorities The Availability, Efficacy/Effectiveness, Cost- effectiveness, Acceptability, and Equity of E-Mental Health Services for Children, Youth, and Young Adults (CIHR GRANT NO. KA1-119794)

3. Did the internet-based intervention work?

4. Anxiety remission rate

5. How did the internet-based intervention compare to usual care (face-to-face)?

6. How long the effect was maintained? Most studies have examined short-term effect (<12 weeks) No studies compared the intervention and control groups >6 months after the intervention 6

7. Conclusion Pooled effect estimates are limited by the small number of studies. Internet-based interventions are effective in reducing anxiety symptoms, and may be as effective as face-to-face interventions. The interventions may not work for depression. 7