1. The Respiratory System

2. Respiratory System

4. Organs of the Respiratory System Upper respiratory system –Nose, nasal cavity, pharynx, glottis and larynx Lower respiratory system –Trachea, bronchus, bronchioles, and lungs –Diaphragm-skeletal muscle; functions in ventilation All airways that carry air to lungs: Nose, pharynx, larynx, trachea bronchi, bronchioles, and terminal bronchioles Sites within lungs where gas exchange occurs Respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli

5. Nose Structure –External nares  nasal cavity  internal nares –Nasal septum divides nose into two sides –Nasal conchae covered by mucous membrane Functions –Warm, humidify, filter/trap dust and microbes Mucus and cilia of epithelial cells lining nose –Detect olfactory stimuli –Modify vocal sounds

6. Large stiff Hairs

7. Nose

8. Sinuses

9. Nasal Cavity

10. Olfactory Receptors

11. Pharynx

12. Known as the “throat” Structure –Funnel-shaped tube from internal nares to larynx Three regions (with tonsils in the upper two) –Upper: nasopharynx; posterior to nose Adenoids and openings of auditory (Eustachian) tubes –Middle: oropharynx; posterior to mouth Palatine and lingual tonsils are here –Lower: laryngopharynx Connects with both esophagus and larynx: food and air

14. larynx “Voice box” Made largely of cartilage –Thyroid cartilage: V-shaped “Adam's apple”: projects more anteriorly in males Vocal cords “mucoso folds –Epiglottis: leaf-shaped piece; covers airway During swallowing, larynx moves up so epiglottis covers opening into trachea-glottis –Cricoid cartilage: inferior most portion –Arytenoids (paired, small) superior to cricoid

15. Larynx

16. Vocal Cords: mucosal folds

18. Lower Respiratory System: Larynx

19. Trachea “Windpipe” Location –Anterior to esophagus and thoracic vertebrae –Extends from end of larynx to primary bronchi Structure –Lined with pseudostratified ciliated columnar mucous membrane: traps and moves dust upward –C-shaped rings of cartilage support trachea, keep lumen open during exhalation Tracheostomy: opening in trachea for tube

20. Trachea

22. The methods outlined above, coughing, backblows, and abdominal thrusts (Heimlich maneuver) have a very high rate of success. In the event, however, that these methods fail to dislodge the obstructing material from the air pipe (trachea), a tracheotomy must be considered.

23. Larynx

24. tracheotomy

25. Cricoid Cartilage

26. Lungs Two lungs: left and right –Right lung has 3 lobes –Left lung has 2 lobes Lungs surrounded by pleural membrane –Parietal pleura attached to diaphragm and lining thoracic wall –Visceral pleura attached to lungs –Pleural cavity with little fluid between pleurae

27. Lung Lobes

28. Bronchi Structure of bronchial tree –Bronchi contain cartilage rings –Primary bronchi enter the right and left lungs –In lungs, branching  secondary bronchi One for each lobe of lung: 3 in right, 2 in left –Tertiary bronchi    terminal bronchioles These smaller airways –Have less cartilage, more smooth muscle. –In asthma, these airways can close.

29. Bronchioles  Respiratory bronchioles –Lined with nonciliated epithelium  Alveolar ducts  Alveolar sacs  Surrounded by alveoli

30. Terminal Alveolar

31. Alveoli Cup-shaped Alveoli: composed of three types of cells –Lined with thin alveolar cells (simple squamous); sites of gas exchange –Surfactant-secreting cells. Surfactant: Lowers surface tension (keeps alveoli from collapsing) Humidifies (keeps alveoli from drying out) –Alveolar macrophages: “cleaners” alveoli + capillary –Gases diffuse across these thin epithelial layers: air  blood

32. Alveolar Sac

33. Surfactants

34. Air Mixture of gases (N 2, O 2,, CO 2, H 2 O, and others) Each gas has own partial pressure, such as P O2 or P N2 Sum of all partial pressures = atmospheric pressure Each gas diffuses down its partial pressure

35. Diffusion Diffusion across alveolar-capillary membrane –O 2 diffuses from air (P O2 ~105 mm Hg) to pulmonary artery (“blue”) blood (P O2 ~40 mm Hg). (Partial pressure gradient = 65 mm Hg) Continues until equilibrium (P O2 ~100-105 mm Hg) –Meanwhile “blue” blood (P CO2 ~45) diffuses to alveolar air (P CO2 ~40) (Partial pressure gradient = 5 mm Hg)

36. Occurs throughout body O 2 diffuses from blood to cells: down partial pressure gradient P O2 lower in cells than in blood because O 2 used in cellular metabolism Meanwhile CO 2 diffuses in opposite direction: cells  blood

37. Internal and External Respiration

38. Transport of Carbon Dioxide CO 2 diffuses from tissues into blood  CO 2 carried in blood: –Some dissolved in plasma (7%) –Bound to proteins including hemoglobin (23%) –Mostly as part of bicarbonate ions (70%) CO 2 + H 2 O  H + + HCO 3 - Process reverses in lungs as CO 2 diffuses from blood into alveolar air  exhaled

39. Transport of Oxygen and Carbon Dioxide

40. External Respiration Bicarbonate ions Carbonic ahydrase Acidosis Alkalosis Carbaminohemoglobin Oxyhemoglobin deoxyhemoglobin

41. Control of Respiration Nervous Control of Breathing is located in the medulla oblongata of brain Chemical control are sensory receptors in the body that are sensitive to chemical composition of body fluids Two sets of chemoreceptors sensitive to pH can cause breathing to speed up. Location: medulla oblongata and in the carotid arteries and aortic bodies. These chemoreceptors are stimulated by the Carbon dioxide concentration.

42. Regulation of Respiratory Center Chemoreceptor input to  increase ventilation –Central receptors in medulla: sensitive to  H+ or PCO2 –Peripheral receptors in arch of aorta + common carotids: respond to  PO2 as well as  H+ or PCO2 in blood Blood and brain pH can be maintained by these negative feedback mechanisms

43. Mechanism of Breathing Inspiration: rib cage moves up and out External intercostal muscles pull the ribs outward Diaphragm contracts and move down When pressure in lungs decreases, air comes rushing in.

44. Expiration Rib cage moves down and in Internal intercostal muscles pull the ribs inward during forced expiration Diaphragm relaxes and move up When pressure in lungs increases, air is pushed out