1. Exam #1 W 2/11 at 7:30-9pm in BUR 106 (bring cheat sheet) Bonuses posted

2. PhenotypeGenotype Dominant Recessive

3. PhenotypeGenotype Genes code for proteins (or RNA). These gene products give rise to traits… It is rarely this simple.

4. What makes us who we are? Nature and Nurture Based on “Nature via Nurture” by Matt Ridley (2003)

5. Imprinting: exposure to movement (environment) sets “mother”

6. X/Y chromosomes in humans: genes = traits

7. Twin studies have been used to determine the heritability of various traits.

8. Types of twins: http://pennhealth.com/health_info/pregnancy/000199.htm

9. Twin studies have been used to determine the heritability of various traits, but there are some caveats: How many twins have been studied? How different are the environments?

10. Correlation of weight (BMI)% Identical twins reared together80 Identical twins reared apart72 Fraternal twins reared together43 Biological siblings34 Parents and children living together26 Adopted children and parents 4 Unrelated children living together 1 *But food preference shows little genetic correlation Correlation of weight and relatedness The nature of environmental influences on weight and obesity: A behavior genetic analysis. Grilo, Carlos M.; Pogue-Geile, Michael F.; Psychological Bulletin, Vol 110(3), Nov 1991. pp. 520-537. And two books by Matt Ridley: Nature via Nurture (2003) and Genome: the Autobiography of a Species in 23 Chapters (1999)

11. Intelligence Correlation of IQ Inheritance :% The same person tested twice87 Identical twins reared together86 Identical twins reared apart76 Fraternal twins reared together55 Biological siblings47 Parents and children living together40 Parents and children living apart31 Adopted children living together 0 Unrelated people living apart 0 From two books by Matt Ridley: Nature via Nurture (2003) and Genome: the Autobiography of a Species in 23 Chapters (1999)

12. When the environment is equal (everyone has access to resources), genetic differences are magnified. When environments are different (only a few have access to resources), environmental differences are magnified.

13. Proof or disproof? Correlation of weight (BMI)% Identical twins reared together80 Identical twins reared apart72 Fraternal twins reared together43 Biological siblings34 Parents and children living together26 Adopted children and parents 4 Unrelated children living together 1 The nature of environmental influences on weight and obesity: A behavior genetic analysis. Grilo, Carlos M.; Pogue-Geile, Michael F.; Psychological Bulletin, Vol 110(3), Nov 1991. pp. 520-537. And two books by Matt Ridley: Nature via Nurture (2003) and Genome: the Autobiography of a Species in 23 Chapters (1999)

14. Can we see a genetic basis for complex behaviors?

15. Voles Prairie Monogamous Both parents care for young Montane Nonmonogamous Mother cares for young briefly

16. Oxytocin (hormone) Water/salt balance Contraction of womb and milk production Encourages bonding between individuals

17. Hormones are molecules produced in one cell and signal another.

18. Oxytocin (hormone) Water/salt balance Contraction of womb and milk production Encourages bonding between individuals

19. Voles Prairie Monogamous Both parents care for young Montane Nonmonogamous Mother cares for young briefly

20. Voles Prairie Monogamous Both parents care for young Montane Nonmonogamous Mother cares for young briefly Same levels of oxytocin

21. Hormones are molecules produced in one cell and signal another.

22. Voles Prairie Monogamous Both parents care for young More receptors Montane Nonmonogamous Mother cares for young briefly Less receptors Same levels of oxytocin

23. Voles Prairie Monogamous Both parents care for young More receptors ? Montane Nonmonogamous Mother cares for young briefly Less receptors ? Same levels of oxytocin Inject hormone into brain

24. Voles Prairie Monogamous Both parents care for young More receptors Monogamous Montane Nonmonogamous Mother cares for young briefly Less receptors Nonmonogamous Same levels of oxytocin Inject hormone into brain

25. Voles Prairie Monogamous Both parents care for young More oxytocin receptors ? Montane Nonmonogamous Mother cares for young briefly Less oxytocin receptors ? Same levels of oxytocin Block receptors

26. Voles Prairie Monogamous Both parents care for young More oxytocin receptors Nonmonogamous Montane Nonmonogamous Mother cares for young briefly Less oxytocin receptors Nonmonogamous Same levels of oxytocin Block receptors

27. Voles Prairie Monogamous Both parents care for young More oxytocin receptors Monogamous Montane Nonmonogamous Mother cares for young briefly Less oxytocin receptors Monogamous Same levels of oxytocin Increase levels of receptors (genetically) in ventral pallidum

28. Voles Prairie Monogamous Both parents care for young More receptors Montane Nonmonogamous Mother cares for young briefly Less receptors Same levels of oxytocin

29. See: http://sciencenow.sciencemag.org/cgi/content/full/2009/203/3?rss=1 (and/or) Disentangling prenatal and inherited influences in humans with an experimental design Frances Ricea, Gordon T. Haroldb, Jacky Boivinb, Dale F. Hayb, Marianne van den Breea, and Anita Thapara PNAS early editioncgidoi10.1073pnas.0808798106 Fetal exposure to smoking can have several affects, including: decreased birth weight increased anti-social behavior

31. Smoke exposure during pregnancy can also have affects delayed affects in adulthood. 17,000 births studied and checked at age 16 and 33. Fetuses exposed to smoking had increased rate of adult obesity and more smoking meant more obesity.

32. Smoke exposure during pregnancy can also have affects delayed affects in adulthood. 17,000 births studied and checked at age 16 and 33. Fetuses exposed to smoking had increased rate of adult obesity and more smoking meant more obesity. For Mom’s who abstained during pregnancy, no effect on fetus or as adult.

33. Smoke exposure during pregnancy can also have affects delayed affects in adulthood. 17,000 births studied and checked at age 16 and 33. Fetuses exposed to smoking had increased rate of adult obesity and more smoking meant more obesity. Smoking during first trimester had same effect as during whole pregnancy.

34. See: http://sciencenow.sciencemag.org/cgi/content/full/2009/203/3?rss=1 (and/or) Disentangling prenatal and inherited influences in humans with an experimental design Frances Ricea, Gordon T. Haroldb, Jacky Boivinb, Dale F. Hayb, Marianne van den Breea, and Anita Thapara PNAS early editioncgidoi10.1073pnas.0808798106 Fetal exposure to smoking can have several affects, including: -decreased birth weight -increased anti-social behavior Are these affects genetic or environmental?

35. In Vitro Fertilization- fertilization occurs in a lab, and then the embryo is implanted into a woman's uterus. Usually the pregnant woman is related to the embryo, but sometimes they are unrelated.

36. The average birth weight for all babies born to smoking mothers was lower...

37. Anti-social behavior was only different if the child and mother were related...

38. Nature and Nurture: Are traits coded for by genes fixed while traits coded for by the environment are under our control?

39. Exam #1 W 2/11 at 7:30-9pm in BUR 106 (bring cheat sheet) Bonuses posted