1. Monday, March 5, 2012  Put your Extra Credit in bin on front desk  Multiple Choice (13/18 or less) AND Short Answer Retakes Must be done in tutorial today and tomorrow  No homework

2. Protein Structure Checkup Version A: #10 Version B: #5 Choose answer A or B for that question.

3. Make an entry- Entry 16- Protein Networks-3/5/12

4. Metabolic Networks Introduction

5. Network Review Network an interconnected or interrelated chain, group, or system. Nodes members of the network Edges the relationships between the nodes

6. Food Network

7. Lactase Lab Lactose is composed of Galactose and Glucose Lactase breaks lactose into…

8. Lactose Lactase How can we represent this with nodes and edges?

9. Lactose Glucose Lactase Galactose

10. Metabolic Network

11. Glycogen UDP-Glucose Lactase Galactose Galactose P UDP-Galactose Glucose-1-P Glucose-6-P Glucose ATP ADP

12. Key Terms Metabolism: all the chemical reactions occurring within a cell or a whole organism Metabolite: any molecule produced by chemical reactions of metabolism

13. A metabolic pathway is a series of enzyme reactions connecting one metabolite to another –Like a single food chain within a food web Click here for animation of metabolic pathway

14. Metabolic Network ABCD E F

15. ABCD E F X

16. C B A X E F D Result: -Accumulation of B -Decrease of C, D, E, and F

17. “Coat Color in Labrador Retrievers” CocoaMidnight

18. Guiding Question: “How does variation exist between organisms?” Read: “Coat Colors in Labrador Retrievers” to help you answer this question.

19. Vocab to know for reading. Pigment = A substance, such as chlorophyll or melanin, that produces a characteristic color in plant or animal tissue. Skin and Hair pigments are produced in cells called melanocytes. Synthesize = to put together.

20. Labrador (dog) pigmentation Tyrosine Dopaquinone Brown pigment Black pigment Yellow pigment tyrosinase TRP-2 TRP-1 What color is the dog’s coat? Black

21. Tyrosine Dopaquinone Brown pigment Black pigment Yellow pigment tyrosinase TRP-2 TRP-1 What would happen if the enzyme TRP – 1 was missing? Black pigment What color is the dog’s coat?Brown

22. Tyrosine Dopaquinone Brown pigment Black pigment Yellow pigment tyrosinase TRP-2 TRP-1 So what would happen if the enzymes TRP – 1 and TRP-2 were both missing? Black pigment What color is the dog’s coat?Yellow Brown pigment