1. BIO-MATERIALS

2. STRUCTURE OF BIO-MATERIALS AND BIO- COMPATIBILITY STRUCTURE OF BIO-MATERIALS AND BIO- COMPATIBILITY IMPLANT MATERIALS IMPLANT MATERIALS POLYMERIC IMPLANT MATERIALS POLYMERIC IMPLANT MATERIALS TISSUE REPLACEMENT IMPLANTS TISSUE REPLACEMENT IMPLANTS ARTIFICIAL ORGANS ARTIFICIAL ORGANS Syllabus - Chapters

3. STRUCTURE OF BIO-MATERIALS AND BIO-COMPATIBILITY Definition and classification of bio-materials Definition and classification of bio-materials Mechanical properties, visco elasticity Mechanical properties, visco elasticity Wound-healing process, Wound-healing process, Body response to implants, Blood compatibility. Body response to implants, Blood compatibility.

4. Definition A biomaterial is a synthetic material used to replace part of a living system or to function in intimate contact with living tissue A biomaterial is a synthetic material used to replace part of a living system or to function in intimate contact with living tissue Commonplace examples include sutures, needles, catheters, plates, tooth fillings, etc Commonplace examples include sutures, needles, catheters, plates, tooth fillings, etc

5. Classification of bio-materials From the point of view of the problem area which is to be solved From the point of view of the problem area which is to be solved

6. By considering the levels of organisation

8. Classification based on materials

9. Mechanical properties The behavior of the material under loading The behavior of the material under loading Two important properties Two important properties STRENGTH STRENGTH STIFFNESS STIFFNESS

11. The load - deformation curve

12. Determinants of strength The load that the structure can sustain before failing The load that the structure can sustain before failing Ultimate failure point Ultimate failure point The deformation it can sustain before failing The deformation it can sustain before failing Slope of the curve - Stiffness Slope of the curve - Stiffness

13. The stress – strain curve (In tension)

14. Stress σ Stress σ Strain ε Strain ε Young ’ s modulus E = σ / ε Young ’ s modulus E = σ / ε Elasticity of a material Elasticity of a material

15. A comparison

16. Mechanical properties of biomaterials

17. Visco elasticity

21. Viscoelasticity The material is subjected to Constant load and its response varies with time The material is subjected to Constant load and its response varies with time Combination of viscous fluid and elastic solid Combination of viscous fluid and elastic solid Two fundamental responses Two fundamental responses Creep Creep Stress relaxation Stress relaxation

22. Creep & Stress relaxation Constant load → rapid initial deformation → slow (time-dependent) progressively increasing deformation → till equilibrium is reached Constant load → rapid initial deformation → slow (time-dependent) progressively increasing deformation → till equilibrium is reached Constant deformation → rapid initial stress → slow (time-dependent) progressively decreasing stress Constant deformation → rapid initial stress → slow (time-dependent) progressively decreasing stress