1. Minimum Module 1 Review Quarterly Assessment 1 Review Bio Keystone Module A

2. BIO.A.1.1 Explain the characteristics of life shared by all prokaryotic and eukaryotic organisms.

3. 2. All need energy for metabolism. Metabolism: All of the chemical processes in an organism that build up or break down materials. What is shared by all living things? An organism is any individual living thing. Living things share some common characteristics: 1. All are made of one or more cells. 3. All respond to their environment. –Stimuli, or physical factors, include light, temperature, and touch. 4. All have genetic material (DNA) that they pass on to offspring.

4. Prokaryotic (no nucleus) & Eukaryotic (yes nucleus) Cells share certain characteristics. 1. Cells tend to be microscopic. 2. All cells are enclosed by a plasma membrane. AKA Cell Membrane 3. All cells are filled with cytoplasm. 4. All cells have ribosomes. (can make proteins aka protein synthesis aka translation). 5. All cells have hereditary material (DNA)

5. BIO.A.2.1 Describe how the unique properties of water support life on Earth. - Describe the unique properties of water and how these properties support life on Earth (ex: freezing point, high specific heat, cohesion)

6. O HH _ ++ Life depends on hydrogen bonds in water. Water is a polar molecule. – Polar molecules have slightly charged regions. – Nonpolar molecules do not have charged regions. 1.Hydrogen bonds form between slightly positive hydrogen atoms and slightly negative atoms. (oxygen) Atom: Oxygen Charge: Slightly negative Atom: Hydrogen Charge: Slightly positive

7. Hydrogen bonds are responsible for important properties of water. –High Specific Heat: water resists changes in temp. –Provides stability of temperature for land masses surrounded by water & for the temperature of the human body, & makes it an effective cooling agent. –Cohesion: water molecules stick to each other. We saw this in the water lab when water built up on the penny & rolled around on the wax paper. –Adhesion: water molecules stick to other things. –Ice floats on water: one of the only solids to float on its liquid form – due to arrangement of water molecules due to charged regions.

8. Freezing Point The freezing point is the temperature and pressure at which a liquid material changes from a liquid to a solid. The freezing point of a liquid can be raised or lowered by adding other chemicals to it, such as by adding salt to water. Molecules slow down when forming a solid and pack tightly. Lipids(fats) tend to have a low freezing point.

9. Properties of Water (cont) Many compounds dissolve in water. A solution is formed when one substance dissolves in another. A solution is a homogeneous mixture. – Solvents dissolve other substances. (i.e. water) – Solutes dissolve in a solvent. (i.e. Koolaid powder) solution

10. Properties of Water (cont) –“ Like dissolves like. ” –Polar solvents dissolve polar solutes. –Nonpolar solvents dissolve nonpolar solutes. –Polar substances and nonpolar substances generally remain separate. –Example: Oil (non-polar) and water (polar)

11. Maintaining homeostasis *Buffer: Helps to maintain pH. Potential Hydrogen Affects Water pH <7=Acid (more H +, less OH - ) 7=Neutral >7=Base (less H +, more OH - )

12. BIO. A.4.2 Explain the mechanisms that permit organisms to maintain biological balance between their internal and external environments. -Explain how organisms maintain homeostasis (ex: thermoregulation, water regulation, oxygen regulation).

13. Speaking of homeostasis… Homeostasis refers to your body maintaining stable, constant internal conditions. This may include: – Regulation of temperature (thermoregulation) Ex.: sweating during exercise – Regulation of pH (buffers) – Regulation of oxygen delivery (for cellular respiration!). Ex: heart beating faster during exercise – - Water regulation (iso, hyper, hypo tonic) osmoregulation - regulation of water concentrations in the bloodstream, effectively controlling the amount of water available for cells to absorb.)

14. Feedback Loops Feedback: Information from sensor that allows a control center to compare current conditions to a set of ideal values. – Feedback loop: Sensor  control center  target  sensor…. Negative feedback loops: control system counteracts any change in the body that moves conditions above or below a set point (reversing change to return conditions to their set points)-most functions in the body are regulated this way. – Ex.: Thermostats, holding your breath Positive feedback loops: Control center uses information to increase rate of change away from set points. – Ex.: Cut finger increases clotting factors in blood.

15. BIO.A.2.2 Describe and interpret relationships between structure and function at various levels of biochemical organization (i.e., atoms, molecules, and macromolecules). Explain how carbon is uniquely suited to form biological macromolecules. Describe how biological macromolecules form from monomers. Compare the structure and function of carbohydrates, lipids, proteins, and nucleic acids in organisms.

16. Definitions Atom: The smallest unit of matter. Consists of a nucleus surrounded by electrons. Molecule: The smallest unit of an element or compound, made up of two or more atoms held together by strong chemical bond.element compound Macromolecule: A large complex molecule, such as nucleic acids, proteins, carbohydrates, and lipids, with relatively large molecular weight.complexmoleculenucleic acidsproteinscarbohydrateslipidsmolecular weight

17. Why Macromolecules? Because….Carbon atoms have unique bonding properties such as: 1. Carbon forms covalent bonds (strong bonds) with up to four other atoms, including other carbon atoms 2. They can form large, complex, diverse molecules

18. 3. Carbon can form single, double, or triple bonds 4. Carbon forms isomers – Isomers are compounds that have the same chemical formula, but different structural formulas Example: C 4 H 10 Only carbon has these 4 characteristics Carbon atoms have unique bonding properties – Slide 2

19. Many carbon-based molecules are made of many small subunits bonded together. Monomers are the individual subunits. Polymers are made of many monomers. When organisms break down large organic compounds (macromolecules), they can obtain energy and/or put the monomers back together to form different compounds.

20. Carbohydrates Monomer monosaccharide Polymerdisaccharide (dimer), polysaccharide ExamplesMonosaccharide: glucose, fructose Disaccharide: sucrose (table sugar) Polysaccharide: starch & cellulose (cell wall in plants), glycogen (in animals) Unique-Provide a quick source of energy

21. Lipids Monomer glycerol & fatty acids; polar heads & fatty acid tails Polymer triglycerides; phospholipids ExamplesFats, oils, cholesterol, steroids, waxes, phospholipids Unique-Nonpolar -Broken down to provide energy -Used to make steroid hormones (control stress, estrogen, testosterone) -Phospholipids make up all cell membranes -Fats and oils contain fatty acids bonded to glycerol -Phospholipids make up all cell membranes (keeps a cell fluid like, more heat = more flexibility in fluid) LIPIDS

22. Proteins Molecule  Proteins MonomerAmino acid PolymerPolypeptide (protein) ExamplesEnzymes (catalyze biochemical reactions), hemoglobin (transports oxygen in blood), muscle movement, collagen Unique-3D structure makes them active -Peptide bonds hold amino acids together -Have a side group (R) that makes each amino acid (and therefore protein) different -Sometimes may contain sulfur

23. Nucleic acids Molecule  Nucleic acids Monomer Nucleotide (5-carbon sugar, phosphate group, & base) PolymerNucleic acid ExamplesDNA & RNA Unique - Order of the bases makes every living thing unique -DNA stores genetic information -RNA builds proteins

24. Dehydration Synthesis Two monomers need to join to make a polymer.

25. Hydrolysis A polymer needs to break apart into monomers. Water is used to do this. (the carbs, proteins, and lipids we ingest are too big for us to use)

26. BIO.A.2.3 Explain how enzymes regulate biochemical reactions within a cell. Describe the role of an enzyme as a catalyst in regulating a specific biochemical reaction. Explain how factors such as pH, temperature, and concentration levels can affect enzyme function.

27. Chemical reactions release or absorb energy. Activation energy is the amount of energy that needs to be absorbed to start a chemical reaction

28. A catalyst lowers activation energy. Catalysts are substances that speed up chemical reactions – Decrease activation energy – Increase reaction rate

29. Enzymes allow chemical reactions to occur under tightly controlled conditions. Enzymes are catalysts in living things. – Enzymes are needed for almost all processes. – Most enzymes are proteins. – Enzymes speed up reactions without being consumed by increasing the reaction rate.

30. Disruptions in homeostasis can prevent enzymes from functioning. Enzymes function best in a small range of conditions. – Changes in temperature or pH, or concentration levels can affect the rate of a reaction, also called DENATURING the enzyme. An enzyme’s function depends on its structure.

31. An enzyme’s structure allows only certain reactants to bind to the enzyme. Substrates: reactants that bind to an enzyme Active site: area on the enzyme where substrates bind

32. Enzyme/Substrate Concentration Enzyme Concentration If we keep the concentration of the substrate constant and increase the concentration of the enzyme, the rate of reaction increases linearly. (That is if the concentration of enzyme is doubled, the rate doubles.) Substrate Concentration If we keep the concentration of the enzyme constant and increase the concentration of the substrate, initially, the rate increases with substrate concentration, but at a certain concentration, the rate levels out and remains constant

33. BIO.B.3.3 Apply scientific thinking, processes, tools, and technologies in the study of the theory of evolution. Distinguish between the scientific terms: hypothesis, inference, law, theory, principle, fact, and observation.

34. 1.3: Scientific Thinking & Processes Key concept: Science is a way of thinking, questioning, and gathering evidence.

35. Science is a process of trying to understand the world around us using critical and logical thinking to evaluate results and conclusions. Scientists gather evidence and share their findings with one another. Observation: the use of our senses, computers, and other tools to gather information about the world. – Ex.: Studying the interactions between gorillas by observing their behavior.

36. Observations can be recorded as data to be analyzed Qualitative data: Descriptions of phenomena that can include sights, sounds, and smells. Quantitative data: Characteristics that can be measured or counted such as mass, volume, and temperature; Numbers

37. Scientists use observations and data to form hypotheses Hypothesis: A proposed, testable answer to a scientific question. – Formal hypotheses are usually written in an “if, then, because” format. – If (change of IV) then (change of DV) because (why you think this will happen).

38. How do scientists test hypotheses? The scientific method – A) Observe and ask questions that lead to a problem – B) Form a hypothesis – C) Test the hypothesis with a controlled experiment by making observations and gathering data. – D) Analyze gathered data – E) Reject (start over at step B) or Accept your hypothesis. – F) Form a conclusion

39. How do scientists test hypotheses? Controlled experiments study the effect of independent variables on dependent variables. Independent variable: A condition that is manipulated, or changed, by a scientist. Effects are measured by changes in dependent variables. Dependent variable: observed and measured during an experiment. – Example: Testing medication to treat blood pressure. IV: medication dose, DV: blood pressure.

40. Controlled experiments Only one independent variable should be changed in an experiment. Other conditions must stay the same and are called constants. Controlled experiments must have a control group – everything is the same as the experimental groups but the independent variable is not manipulated. – Example: When testing blood pressure medication, control group receives none of the active ingredient. A large number of test subjects or trials is ideal.

41. Other important science terms Inference: A conclusion reached on the basis of evidence and reasoning. (Ex: you make an inference when you use clues to figure something out). Law: A law that generalizes a body of observations. At the time it is made, no exceptions have been found to a law. It explains things but does not describe them; serves as the basis of scientific principles. (Ex: Law of Gravity, Newton’s Laws of motion). Theory: A proposed explanation for observations and experimental results that is supported by a wide range of evidence – may eventually be accepted by the scientific community. (Ex: Big Bang Theory, Evolution & Natural Selection) Principle: A concept based on scientific laws and axioms (rules assumed to be present, true, and valid) where general agreement is present. (Ex: Buoyancy Principle) Fact: An observation that has been repeatedly confirmed.