1. Population Dynamics Humans and malaria

2. Science (2010), v.328:841

3. Global Map of Malaria “…a far more urgent task: reducing the horrific toll of malaria in central Africa, where five countries account for 50% of all global deaths from the disease and elimination is not possible.” Science (2010), v.328:849

4. Malaria

5. Malaria life cycle http://www.cdc.gov/malaria/about/index.html http://www.who.int/topics/malaria/en/

6. Malaria is large threat to human health in equatorial regions of the Earth But some human populations show resistance to the disease. How??

7. Natural Selection Overproduction Environmental pressure/competition Pre-existing individual variation Heritable traits Happens over generations (time) Happens in populations (not single individuals) Offspring must be viable and fertile

8. Darwin’s Inescapable Conclusion –Fact 1: Potential for overproduction and competition for existence –Fact 2: Individual variation –The inescapable conclusion: Unequal reproductive success Darwin called this process natural selection. The result of natural selection is evolution when a population has adapted to its environment. Evidence for humans?

9. Human Population Growth The History of Global Population Growth

10. Darwin’s Inescapable Conclusion –Fact 1: Potential for overproduction and competition for existence –Fact 2: Individual variation –The inescapable conclusion: Unequal reproductive success Darwin called this process natural selection. The result of natural selection is evolution when a population has adapted to its environment. Evidence for humans?

11. The Modern Synthesis: Darwinism Meets Genetics –The modern synthesis is the fusion of genetics with evolutionary biology. Copyright © 2007 Pearson Education Inc., publishing as Pearson Benjamin Cummings

12. Populations as the Units of Evolution –A population Is a group of individuals of the same species living in the same place at the same time. Is the smallest biological unit that can evolve.

13. –Population genetics Focuses on populations as the evolutionary units. Tracks the genetic makeup of populations over time.

14. Genetic Variation in Populations –Individual variation abounds in populations. Not all of this variation is heritable. Only the genetic component of variation is relevant to natural selection.

15. Sources of Genetic Variation in sexually reproducing organisms –Mutations Are changes in the DNA of an organism. –Sexual recombination Crossing over Independent assortment of chromosomes Random fertilization

16. –Hemophilia Is a blood-clotting disease.

17. Intergenerational Mutation Rate By how many mutations does your genome differ from your parents genome? Roach et al (2010) found about 60 mutations, 30 from each parent, that occurred during the formation of egg and sperm (meiosis).

19. Sickle-cell allele: genotype, phenotype, and resistance to malaria from The Human Evolution Coloring Book, 2nd Ed. Malaria infection causes cells to sickle. Sickled cells, along with parasite, are killed.

20. Sickle-cell Allele

21. Biochemistry of sickle-cell disease from Steinberg, M.H., (2006), Trends Pharm. Sci., 27(4):204-210.

22. Sources of Genetic Variation in sexually reproducing organisms –Mutations Are changes in the DNA of an organism. –Sexual recombination Crossing over Independent assortment of chromosomes Random fertilization

23. –Sexual reproduction depends on Production of gametes through Meiosis. Fertilization. Meiosis, The Basis of Sexual Reproduction Copyright © 2007 Pearson Education, Inc. publishing as Pearson Benjamin Cummings

24. Gametes and the Life Cycle of a Sexual Organism –The life cycle of a multicellular organism is the sequence of stages leading from the adults of one generation to the adults of the next.

25. Figure 8.14 –Humans are diploid organisms. Their cells contain two sets of chromosomes Their gametes are haploid, having only one set of chromosomes

26. – Fertilization Is the fusion of sperm and egg. Creates a zygote, or fertilized egg. –Sexual life cycles involve an alternation of diploid and haploid stages.

27. Eukaryotic Chromosomes –Each eukaryotic chromosome contains one very long DNA molecule, Typically bearing thousands of genes. –The number of chromosomes in a eukaryotic cell Depends on the species.

28. –Homologous chromosomes are matching pairs of chromosomes. –Humans have Two different sex chromosomes, X and Y. A female has XX A male has XY Twenty-two pairs of matching chromosomes, called autosomes. Homologous Chromosomes

29. Meiosis is the process where the two sets of homologous chromosomes are separated into different cells - egg or sperm. Start with one cell with 2 sets of homologous chromosomes End with 4 cells with 1 set of homologous chromosomes How does this happen?

30. Meiosis is the process where the two sets of homologous chromosomes are separated into different cells - egg or sperm.

31. The Process of Meiosis –In meiosis, Haploid daughter cells are produced in diploid organisms. Two consecutive divisions occur, meiosis I and meiosis II, preceded by interphase. Crossing over occurs. From movie folder play: MeiosisOverview.htmlTelophaseICytokin.html Interphase.htmlProphaseII.html ProphaseI.htmlMetaphaseII.html MetaphaseI.htmlAnaphaseII.html AnaphaseI.htmlTelophaseIICytokin.html

32. Figure 8.16.1

33. Figure 8.16.2

34. Figure 8.16.3

35. Review: Comparing Mitosis and Meiosis –All the events unique to meiosis occur during meiosis I.

36. Figure 8.17

37. The Origins of Genetic Variation –Offspring of sexual reproduction are genetically different from their parents and from one another. –Independent assortment of chromosomes –Random fertilization –Crossing over –Random mutations

38. Independent Assortment of Chromosomes –In independent assortment, every chromosome pair orients independently of the others during meiosis.

39. Random Fertilization –The human egg cell is fertilized randomly by one sperm, leading to genetic variety in the zygote.

40. Crossing Over –In crossing over, Homologous chromosomes exchange genetic information. Genetic recombination occurs. From the movie folder play: - CrossingOver.html

41. –What happens when errors occur in meiosis? When Meiosis Goes Awry

42. How Accidents During Meiosis Can Alter Chromosome Number –In nondisjunction, The members of a chromosome pair fail to separate during anaphase. Gametes with an incorrect number of chromosomes are produced. Copyright © 2007 Pearson Education, Inc. publishing as Pearson Benjamin Cummings

43. Figure 8.20

44. –The result of nondisjunction

45. Down Syndrome: An Extra Chromosome 21 –Down Syndrome Is a condition where an individual has an extra chromosome 21. Is also called trisomy 21.

46. –The incidence of Down Syndrome increases with the age of the mother.

47. Abnormal Numbers of Sex Chromosomes –Nondisjunction Also affects the sex chromosomes.